SynthesisEnvironmental science and pollution research international2020
Impact of chlorpyrifos on blood glucose concentration in an animal model: a systematic review and meta-analysis.
Synthesis in Environmental science and pollution research international, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 2 syntheses or guidelines pooled it, 22 citations in OpenAlex.
- The effect of diazinon on blood glucose homeostasis: a systematic and meta-analysis study.Environmental science and pollution research international · 2021Pooled it
- The association between diazinon exposure and dyslipidemia occurrence: a systematic and meta-analysis study.Environmental science and pollution research international · 2021Pooled it
- Next-generation biodegradation of chlorpyrifos: integrative microbial strategies, molecular mechanisms, and environmental impacts.Biodegradation · 2026Review
- Prenatal exposure to agricultural pesticide applications and gestational diabetes mellitus in the Az-PEARS population-based study (2014-2020).Environment international · 2026Article
- From toxicogenomics data to cumulative assessment groups: a framework for chemical grouping.Archives of toxicology · 2026Article
- Review
- High-Fat Diet Aggravates the Disorder of Glucose Metabolism Caused by Chlorpyrifos Exposure in Experimental Rats.Foods (Basel, Switzerland) · 2023Article
- Retinal Toxicity Induced by Chemical Agents.International journal of molecular sciences · 2022Review
- Mechanism and kinetics of chlorpyrifos co-metabolism by using environment restoring microbes isolated from rhizosphere of horticultural crops under subtropics.Frontiers in microbiology · 2022Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chlorpyrifos, an organophosphate insecticide, disturbs blood glucose hemostasis in experimental models and causes metabolic disorders. However, there are controversial findings of its impact on the BS level. The present meta-analysis aimed to investigate blood gluocse levels in rats exposed to chlorpyrifos. Present systematic review and meta-analysis study was done by searching in the online databases, including Google Scholar, Web of Science, PubMed, and Scopus. Data were analyzed by performing "random effects meta-regression." Findings were expressed as standardized mean value and 95% confidence interval (CI). Heterogeneity between studies was assessed using I-square and Q test. Meta-analysis of 7 animal studies indicated the dose-dependence manner of chlorpyrifos exposure on the blood glucose levels. The subgroup analysis indicated that exposure to low doses of chlorpyrifos significantly increased the blood glucose levels in exposed animals versus the nonexposed (0.11; 95% CI: - 1.14, 1.36, z = 2.25, p = 0.03, I2 = 90.1%, p < 0.001) and high doses markedly decreased blood glucose levels in exposed rats versus the nonexposed (7.34; 95%CI: - 9.35, - 5.32, z = 6.41, p < 0.001, I2 = 96.9%, p < 0.001). The random effects and pooled analysis indicated that the blood glucose levels were 4.22-fold lower in exposed animals versus the nonexposed ones (95% CI: - 5.59,- 2.85; Z = 3.97; p < 0.001); therefore, heterogeneity was significant (I2 = 96.5%, p < 0.001). The present finding indicated the association between chlorpyrifos exposure and a decrease in blood glucose levels. However, more studies should be designed to clarify this effect of chlorpyrifos exposure on blood glucose levels and involved mechanisms.
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