ArticleEnvironmental science and pollution research international2020
Gallic acid affects blood-brain barrier permeability, behaviors, hippocampus local EEG, and brain oxidative stress in ischemic rats exposed to dusty particulate matter.
Article in Environmental science and pollution research international, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 47 citations in OpenAlex.
- Serum metabolic fingerprinting for diagnosis and therapeutic applications of ovarian endometriosis.iScience · 2026Article
- Antioxidant and neuromodulatory effect of gallic acid prevents anxiety-like symptoms of omeprazole.RSC advances · 2026Article
- Nitrooxidative Stress and Neuroinflammation Caused by Air Pollutants Are Associated with the Biological Markers of Neurodegenerative Diseases.Antioxidants (Basel, Switzerland) · 2024Review
- Neuroimaging Approach: Effects of Hot and Cold Germinated Wheat Beverages on Electroencephalographic (EEG) Activity of the Human Brain.Foods (Basel, Switzerland) · 2023Article
- Gallic Acid Ameliorates Cognitive Impairment Caused by Sleep Deprivation through Antioxidant Effect.Experimental neurobiology · 2023Article
- Apitherapy in Post-Ischemic Brain Neurodegeneration of Alzheimer's Disease Proteinopathy: Focus on Honey and Its Flavonoids and Phenolic Acids.Molecules (Basel, Switzerland) · 2023Review
- Review
- A Review on Polyphenols inNutrients · 2023Review
- Sesamin alleviates defects in seizure, behavioral symptoms, and hippocampus electroencephalogram in a pentylenetetrazol rat model.Iranian journal of basic medical sciences · 2023Article
- Role of traditional Chinese medicine monomers in cerebral ischemia/reperfusion injury:a review of the mechanism.Frontiers in pharmacology · 2023Review
- Anti-migraine activity of freeze-dried latex obtained from Calotropis gigantea Linn.Environmental science and pollution research international · 2022Article
- Effects of Natural Polyphenols on Oxidative Stress-Mediated Blood-Brain Barrier Dysfunction.Antioxidants (Basel, Switzerland) · 2022Review
- Therapeutic Effects of Resveratrol on Ischemia-Reperfusion Injury in the Nervous System.Neurochemical research · 2021Review
- Powdered Green Tea (Matcha) Attenuates the Cognitive Dysfunction via the Regulation of Systemic Inflammation in Chronic PMAntioxidants (Basel, Switzerland) · 2021Article
- Estimation of PMEnvironmental science and pollution research international · 2021Article
- A mechanistic view on the neurotoxic effects of air pollution on central nervous system: risk for autism and neurodegenerative diseases.Environmental science and pollution research international · 2021Review
- Gallic Acid Alleviates Neuropathic Pain Behaviors in Rats by Inhibiting P2X7 Receptor-Mediated NF-κB/STAT3 Signaling Pathway.Frontiers in pharmacology · 2021Article
- Gallic Acid Prevents the Oxidative and Endoplasmic Reticulum Stresses in the Hippocampus of Adult-Onset Hypothyroid Rats.Frontiers in pharmacology · 2021Article
- Role of Polyphenols as Antioxidant Supplementation in Ischemic Stroke.Oxidative medicine and cellular longevity · 2021Review
- From Preclinical Stroke Models to Humans: Polyphenols in the Prevention and Treatment of Stroke.Nutrients · 2020Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Dust storms are environmental natural events that transport high concentrations of particulate matter (PM) in living spaces. Recent epidemiological studies have shown that air pollution is associated with stroke. In the present study we aimed to investigate the probable protective effects of gallic acid (GA) on blood-brain barrier (BBB) disruption, brain oxidative stress, anxiety, depression, locomotion behaviors, and changes of hippocampal local electroencephalogram (local EEG) power induced by 4-vessel transient occlusion (4VO I/R) following exposure to dusty PM in rats. Male Wistar rats were divided randomly into eight groups: (1) vehicle+Sham (Veh + Sh), (2) vehicle+4VO I/R (Veh + I/R), (3) gallic acid+sham (GA + Sh), (4) gallic acid+4VO I/R (GA + I/R), (5) vehicle+PM (Veh + PM), (6) PM + 4VO I/R (PM + I/R), (7) gallic acid+PM + Sham (GA + PM + Sh), and (8) gallic acid+PM + 4Vo I/R (GA + PM + I/R). 4VO type of I/R was induced after 10 days of pretreatment by GA 100 mg/kg/2 ml/ip, or 2 ml/kg/ip, normal saline as vehicle (Veh) and exposure to dust storm composed of dusty PM (DPM, 2000-8000 μg/m3), 60 min daily for consecutive 10 days) simultaneously. Seventy-two hours after I/R induction, all behavioral tests and BBB permeability evaluation were done. Hippocampus local EEG was recorded just before and 72 h after I/R induction, and finally brain tissue oxidative stress was assayed. Data showed that 4VO I/R following exposure to DPM increased BBB permeability (p < 0.001), brain oxidative stress (p < 0.001), induced anxiety (p < 0.001), depression (p < 0.01), locomotion impairment (p < 0.001), superoxide dismutase (SOD) activity, and local EEG power also were decreased in PM + Sh (p < 0.001). Pretreatment with GA reversed BBB permeability and MDA. Our findings suggest that GA is a probable protective agent against adverse effects of both I/R and exposure to DPM and also in I/R subjects exposed to DPM. The beneficial effects of GA may induce by its antioxidative and anti-inflammatory properties.
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