Evidence map›Paper›PMID 31848935›Full record

ArticleMolecular neurobiology2020

Validation of Poly(Propylene Imine) Glycodendrimers Towards Their Anti-prion Conversion Efficiency.

Matthias Schmitz, Niccolo Candelise, Eirini Kanata, Franc Llorens, Katrin Thüne, Anna Villar-Piqué, Susana Margarida da Silva Correia, Dimitra Dafou, Theodoros Sklaviadis, Dietmar Appelhans and 1 more

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular neurobiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Review
  3. Synthesis, structural characterization and study of antioxidant and anti-PrPJournal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2023
    Article
  4. Article
  5. Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 3 countries.

Matthias SchmitzDepartment of Neurology, University Medicine Goettingen and the German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany. matthias.schmitz@med.uni-goettingen.de.ORCID http://orcid.org/0000-0002-5502-681X
Niccolo CandeliseDepartment of Neurology, University Medicine Goettingen and the German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany.
Eirini KanataPrion Diseases Research Group, School of Pharmacy, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Franc LlorensDepartment of Neurology, University Medicine Goettingen and the German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany.
Katrin ThüneDepartment of Neurology, University Medicine Goettingen and the German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany.
Anna Villar-PiquéDepartment of Neurology, University Medicine Goettingen and the German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany.
Susana Margarida da Silva CorreiaDepartment of Neurology, University Medicine Goettingen and the German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany.
Dimitra DafouDepartment of Genetics, Development and Molecular Biology, School of Biology, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Theodoros SklaviadisPrion Diseases Research Group, School of Pharmacy, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Dietmar AppelhansLeibniz-Institut für Polymerforschung Dresden e.V., Hohe Str. 6, D-01069, Dresden, Germany.ORCID http://orcid.org/0000-0003-4611-8963
Inga ZerrDepartment of Neurology, University Medicine Goettingen and the German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany.
German Center for Neurodegenerative Diseases · DEAristotle University of Thessaloniki · GRLeibniz Institute of Polymer Research · DE

Funding

DAAD 57421248Spanish Ministry of Health-Instituto Carlos III CP16/00041
6 · The paper itself

Abstract

Prion diseases, such as the sporadic Creutzfeldt-Jakob disease (sCJD), are a class of fatal neurodegenerative disorders. Currently, there is no efficient treatment or therapy available. Hence, the search for molecules that may inhibit the conversion of the cellular prion protein (PrP

Indexed as

BrainCell Line, TumorCreutzfeldt-Jakob SyndromeDendrimersFluorescein-5-isothiocyanateGlycosylationHumansModels, MolecularPolypropylenesPrionsProtein AggregatesReproducibility of ResultsDendrimersFluorescein-5-isothiocyanatepoly(propyleneimine)PolypropylenesPrionsProtein AggregatesCerebrospinal fluidCreutzfeldt-Jakob diseasePoly(propylene imine) (PPI) glycodendrimerPrion proteinReal-time quaking-induced conversion assay

Identifiers

PMID31848935
OpenAlexW2994619903

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.