Evidence map›Paper›PMID 31848875›Full record

ArticleJournal of thrombosis and thrombolysis2020

Validation of an algorithm to predict decline in INR following warfarin cessation in patients undergoing invasive procedures.

Emmanouela Kampouraki, Hilary Wynne, Peter Avery, Farhad Kamali

Abstract readValidation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of thrombosis and thrombolysis, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Emmanouela KampourakiTranslational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.ORCID http://orcid.org/0000-0002-8384-5943
Hilary WynneOlder People's Medicine, Freeman Hospital, Newcastle upon Tyne, UK.
Peter AverySchool of Mathematics Statistics and Physics, Newcastle University, Newcastle upon Tyne, UK.
Farhad KamaliTranslational and Clinical Research Institute, Newcastle University and Newcastle upon Tyne Hospitals, NHS Foundation Trust, Newcastle upon Tyne, NE1 7RU, UK. farhad.kamali@ncl.ac.uk.ORCID http://orcid.org/0000-0002-8401-4017

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Patients on warfarin are required to withdraw from treatment for a fixed period (normally 5 days) prior to an invasive procedure. However, the anticoagulant effect of warfarin subsides at different rates among different patients, exposing some to increased risk of either thrombosis or bleeding. In a recent study in patients awaiting surgery, following warfarin cessation the INR declined slower over time in those with two CYP2C9 variant alleles, increasing age, weight and number of comorbidities and that INR decline was faster in those with higher maintenance INR value. Subsequently, we developed an algorithm which predicts INR decline in individual patients after 5 days of warfarin cessation. The current study validated the algorithm. An independent cohort of patients completing a short course of warfarin took part in the study. INR values for subsequent 9 days and CYP2C9 genotype were available. The predicted INR decline (INR

Indexed as

International Normalized RatioAdultAgedAged, 80 and overAlgorithmsAnticoagulantsBlood CoagulationCohort StudiesFemaleHumansMaleMiddle AgedWarfarinAnticoagulantsWarfarinAlgorithmCytochrome P-450 CYP2C9GenotypeInternational normalized ratioWarfarin

Identifiers

PMID31848875
PMCPMC7182614

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.