ArticleFish physiology and biochemistry2020
Humoral immune responses and gill antioxidant-related gene expression of common carp (Cyprinus carpio) exposed to lufenuron and flonicamide.
Article in Fish physiology and biochemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 17 citations in OpenAlex.
- Residue Dissipation, Transformation Products, and Dietary Risk Assessment of Flonicamid in a Rice Paddy Ecosystem.Foods (Basel, Switzerland) · 2026Article
- Mechanisms of Pesticide Toxicity in Fish: Insights Into the Ameliorative Role of Plant-Derived Compounds-A Review.Aquaculture nutrition · 2025Review
- Lufenuron induces reproductive toxicity and genotoxic effects in pregnant albino rats and their fetuses.Scientific reports · 2020Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to investigate plasma proteins, total immunoglobulin (Ig), lysozyme and complement (ACH50) levels, and gill superoxide dismutase (SOD) and catalase (CAT) gene expression in common carp (Cyprinus carpio), following exposure to lufenuron (LUF) and flonicamide (FL). Fish were distributed in 12 tanks as three quadrupled treatments: control (fish were kept in pesticide-free water), LUF [fish exposed to 10% of LUF LC50 (4.3 mg/L)], and FL [fish exposed to 10% of FL LC50 (0.1 mg/L)]. The plasma parameters were assessed after 7 and 21 days exposure to pesticides, whereas the gene expressions were assessed after 21 days. The results showed that LUF exposure significantly decreased plasma total protein and globulin levels compared to the control group. Both pesticide significantly decreased plasma total Ig levels compared to the control group; however, LUF exhibited a greater effect. There were no significant effects of pesticides or sampling time on plasma ACH50 activity. Pesticides and sampling time interacted to affect plasma lysozyme activity. Seven days after exposure, both pesticides significantly increased lysozyme activity, and the effect of FL was greater than LUF. Nevertheless, there was no significant difference in plasma lysozyme activities among the pesticides, 21 days after the exposure. Both pesticides significantly decreased SOD and CAT gene expression, nevertheless, FL exhibited greater effects than LUF. In conclusion, both pesticides induced immunosuppression in the fish, though such effects were more severe in LUF group, compared to the FL. These pesticides negatively affect expression of gill antioxidant genes, and the FL effects were greater than the LUF.
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