Evidence map›Paper›PMID 31848596›Full record

ArticleDatabase : the journal of biological databases and curation2019

RHPCG: a database of the Regulation of the Hippo Pathway in Cancer Genome.

Chengyu Wang, Fan Yang, Tingting Chen, Qi Dong, Zhangxiang Zhao, Yaoyao Liu, Bo Chen, Haihai Liang, Huike Yang, Yunyan Gu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Database : the journal of biological databases and curation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Chengyu WangCollege of Bioinformatics Science and Technology, Harbin Medical University, Baojian Road, Nangang District, Harbin, 150086, China.
Fan YangCollege of Bioinformatics Science and Technology, Harbin Medical University, Baojian Road, Nangang District, Harbin, 150086, China.
Tingting ChenCollege of Bioinformatics Science and Technology, Harbin Medical University, Baojian Road, Nangang District, Harbin, 150086, China.
Qi DongCollege of Bioinformatics Science and Technology, Harbin Medical University, Baojian Road, Nangang District, Harbin, 150086, China.
Zhangxiang ZhaoCollege of Bioinformatics Science and Technology, Harbin Medical University, Baojian Road, Nangang District, Harbin, 150086, China.
Yaoyao LiuCollege of Bioinformatics Science and Technology, Harbin Medical University, Baojian Road, Nangang District, Harbin, 150086, China.
Bo ChenCollege of Bioinformatics Science and Technology, Harbin Medical University, Baojian Road, Nangang District, Harbin, 150086, China.
Haihai LiangDepartment of Pharmacology, Harbin Medical University, Baojian Road, Nangang District, Harbin 150086, China.
Huike YangDepartment of Anatomy, Harbin Medical University, Baojian Road, Nangang District, Harbin 150086, China.
Yunyan GuCollege of Bioinformatics Science and Technology, Harbin Medical University, Baojian Road, Nangang District, Harbin, 150086, China.
Harbin Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Hippo signaling pathway is a highly conserved pathway controlling organ size, cell proliferation, apoptosis and other biological functions. Recent studies have shown that Hippo signaling pathway also plays important roles in cancer initiation and progression. However, a database offering multi-omics analyses and visualization of Hippo pathway genes in cancer, as well as comprehensive Hippo regulatory relationships is still lacking. To fill this gap, we constructed the Regulation of the Hippo Pathway in Cancer Genome (RHPCG) database. Currently, RHPCG focuses on analyzing the 21 core Hippo-protein-encoding genes in over 10 000 patients across 33 TCGA (The Cancer Genome Atlas) cancer types at the levels of genomic, epigenomic and transcriptomic landscape. Concurrently, RHPCG provides in its motif section 11 regulatory motif types associated with 21 core Hippo pathway genes containing 180 miRNAs, 6182 lncRNAs, 728 circRNAs and 335 protein coding genes. Thus, RHPCG is a powerful tool that could help researchers understand gene alterations and regulatory mechanisms in the Hippo signaling pathway in cancer.

Indexed as

Databases, GeneticGenomeSignal TransductionGene Regulatory NetworksHumansNeoplasmsNucleotide MotifsProtein Serine-Threonine KinasesUser-Computer InterfaceProtein Serine-Threonine KinasesCancer genomeHippo signaling pathwayRegulatory motifThe Cancer Genome Atlas

Identifiers

PMID31848596
PMCPMC6917511
OpenAlexW2994801885

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.