Trial reportScientific reports2019
Characterization of multi-channel intraneural stimulation in transradial amputees.
Trial report in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 69 citations in OpenAlex.
- Artificial referred sensation in upper and lower limb prosthesis users: a systematic review.Journal of neural engineering · 2022Pooled it
- Foreign Body Reaction to Implanted Biomaterials and Its Impact in Nerve Neuroprosthetics.Frontiers in bioengineering and biotechnology · 2021Pooled it
- Scaling beyond the vagus nerve: historical and contemporary progress on electrode-based small-diameter peripheral nerve interfaces.Bioelectronic medicine · 2026Review
- Sensory feedback for gait in transtibial amputees: a narrative review of technologies and clinical outcomes.Frontiers in bioengineering and biotechnology · 2025Review
- Clinical Applications and Future Translation of Somatosensory Neuroprostheses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Review
- Sensory integration for neuroprostheses: from functional benefits to neural correlates.Medical & biological engineering & computing · 2024Review
- A Sensory Feedback Neural Stimulator Prototype for Both Implantable and Wearable Applications.Micromachines · 2024Article
- Electrical Stimulation of Regenerative Peripheral Nerve Interfaces (RPNIs) Induces Referred Sensations in People With Upper Limb Loss.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2024Article
- Sensory Restoration for Improved Motor Control of Prostheses.Current opinion in biomedical engineering · 2023Article
- Multilayer Arrays for Neurotechnology Applications (MANTA): Chronically Stable Thin-Film Intracortical Implants.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Flexible IrOActa biomaterialia · 2023Article
- A novel ex-vivo isolated rabbit heart preparation to explore the cardiac effects of cervical and cardiac vagus nerve stimulation.Scientific reports · 2023Article
- Electrical nerve stimulation for sensory-neural pathway reconstruction in upper-limb amputees.Frontiers in neuroscience · 2023Article
- Sensory stimulation for upper limb amputations modulates adaptability of cortical large-scale systems and combination of somatosensory and visual inputs.Scientific reports · 2022Article
- Peripheral neurostimulation for encoding artificial somatosensations.The European journal of neuroscience · 2022Review
- Preliminary Evaluation of the Effect of Mechanotactile Feedback Location on Myoelectric Prosthesis Performance Using a Sensorized Prosthetic Hand.Sensors (Basel, Switzerland) · 2022Article
- Sensorimotor integration within the primary motor cortex by selective nerve fascicle stimulation.The Journal of physiology · 2022Article
- On a high photocatalytic activity of high-noble alloys Au-Ag/TiOScientific reports · 2022Article
- Distinct spatio-temporal and spectral brain patterns for different thermal stimuli perception.Scientific reports · 2022Article
- Short-pulsed micro-magnetic stimulation of the vagus nerve.Frontiers in physiology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 7 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although peripheral nerve stimulation using intraneural electrodes has been shown to be an effective and reliable solution to restore sensory feedback after hand loss, there have been no reports on the characterization of multi-channel stimulation. A deeper understanding of how the simultaneous stimulation of multiple electrode channels affects the evoked sensations should help in improving the definition of encoding strategies for bidirectional prostheses. We characterized the sensations evoked by simultaneous stimulation of median and ulnar nerves (multi-channel configuration) in four transradial amputees who had been implanted with four TIMEs (Transverse Intrafascicular Multichannel Electrodes). The results were compared with the characterization of single-channel stimulation. The sensations were characterized in terms of location, extent, type, and intensity. Combining two or more single-channel configurations caused a linear combination of the sensation locations and types perceived with such single-channel stimulations. Interestingly, this was also true when two active sites from the same nerve were stimulated. When stimulating in multi-channel configuration, the charge needed from each electrode channel to evoke a sensation was significantly lower than the one needed in single-channel configuration (sensory facilitation). This result was also supported by electroencephalography (EEG) recordings during nerve stimulation. Somatosensory potentials evoked by multi-channel stimulation confirmed that sensations in the amputated hand were perceived by the subjects and that a perceptual sensory facilitation occurred. Our results should help the future development of more efficient bidirectional prostheses by providing guidelines for the development of more complex stimulation approaches to effectively restore multiple sensations at the same time.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.