ArticleNature communications2019
Multi-scale imaging and analysis identify pan-embryo cell dynamics of germlayer formation in zebrafish.
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 66 citations in OpenAlex.
- Single-cell morphodynamics predict cell fate decisions during mucociliary epithelial differentiation.Molecular systems biology · 2026Article
- Ex vivo imaging reveals neutrophil behaviors in the adult zebrafish heart.Journal of cell science · 2026Article
- High-Fidelity Long-term Whole-embryo Lineage and Fate Reconstruction by Iterative Tracking with Error Correction.bioRxiv : the preprint server for biology · 2026Article
- Unravelling the progression of the zebrafish primary body axis with reconstructed spatiotemporal transcriptomics.Genome biology · 2026Article
- Visualizing the multidimensional landscape of biological variation in modern microscopy.Frontiers in bioinformatics · 2026Article
- Endodermal cells use contact inhibition of locomotion to achieve uniform cell dispersal during zebrafish gastrulation.iScience · 2025Article
- Single-cell morphodynamics predict cell fate decisions during mucociliary epithelial differentiation.bioRxiv : the preprint server for biology · 2025Article
- Ultrack: pushing the limits of cell tracking across biological scales.Nature methods · 2025Article
- In toto analysis of embryonic organisation reduces tissue diversity to two archetypes requiring specific cadherins.Nature communications · 2025Article
- A toolkit for mapping cell identities in relation to neighbors reveals conserved patterning of neuromesodermal progenitor populations.PLoS biology · 2025Article
- Tetrahedral serial multiview microscopy and image fusion for improved resolution and extent in stained zebrafish embryos.Developmental dynamics : an official publication of the American Association of Anatomists · 2024Article
- Image restoration of degraded time-lapse microscopy data mediated by near-infrared imaging.Nature methods · 2024Article
- Enabling neighbour labelling: using synthetic biology to explore how cells influence their neighbours.Development (Cambridge, England) · 2024Review
- An archetype and scaling of developmental tissue dynamics across species.Nature communications · 2023Article
- Compact, high-speed multi-directional selective plane illumination microscopy.Biomedical optics express · 2023Article
- Learning hydrodynamic equations for active matter from particle simulations and experiments.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Second-order division in sectors as a prepattern for sensory organs in vertebrate development.Theory in biosciences = Theorie in den Biowissenschaften · 2022Article
- A biaxial tensional model for early vertebrate morphogenesis.The European physical journal. E, Soft matter · 2022Article
- DaXi-high-resolution, large imaging volume and multi-view single-objective light-sheet microscopy.Nature methods · 2022Article
- The unappreciated generative role of cell movements in pattern formation.Royal Society open science · 2022Review
Corrections and comments
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Authors and funding
9 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The coordination of cell movements across spatio-temporal scales ensures precise positioning of organs during vertebrate gastrulation. Mechanisms governing such morphogenetic movements have been studied only within a local region, a single germlayer or in whole embryos without cell identity. Scale-bridging imaging and automated analysis of cell dynamics are needed for a deeper understanding of tissue formation during gastrulation. Here, we report pan-embryo analyses of formation and dynamics of all three germlayers simultaneously within a developing zebrafish embryo. We show that a distinct distribution of cells in each germlayer is established during early gastrulation via cell movement characteristics that are predominantly determined by their position in the embryo. The differences in initial germlayer distributions are subsequently amplified by a global movement, which organizes the organ precursors along the embryonic body axis, giving rise to the blueprint of organ formation. The tools and data are available as a resource for the community.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.