ArticleNature communications2019
An artificial metalloenzyme biosensor can detect ethylene gas in fruits and Arabidopsis leaves.
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 95 citations in OpenAlex.
- Harnessing endogenous carbon monoxide for cancer-selective drug synthesis.Nature communications · 2026Article
- VOC biomarker-based wearable gas sensors for real-timeFrontiers in plant science · 2026Review
- Recent progress of gas sensors toward olfactory display development.Nano convergence · 2025Review
- Insights of freshness phenotype detection for postharvest fruit and vegetables.Plant phenomics (Washington, D.C.) · 2025Review
- An Amplificative Detection Approach for Autocatalytic Sensing of Ethylene.Journal of the American Chemical Society · 2025Article
- Modulation of plant growth and development through altered ethylene binding affinity of the ethylene receptor ETR1.BMC plant biology · 2025Article
- Ethylene Signaling in Plant Development and Stress Adaptation.Methods in molecular biology (Clifton, N.J.) · 2025Article
- The Role of Ethylene and Its Antagonists in Advancing Postharvest Management of Fruits and Flowers.Methods in molecular biology (Clifton, N.J.) · 2025Article
- A Review of Methodologies for the Rapid Analysis and Quantification of Gases in Solid Media.Sensors (Basel, Switzerland) · 2024Review
- Chemistry-driven translocation of glycosylated proteins in mice.Nature communications · 2024Article
- Revisiting the Role of Sensors for Shaping Plant Research: Applications and Future Perspectives.Sensors (Basel, Switzerland) · 2024Review
- A Transfer Hydrogenation Approach to Activity-Based Sensing of Formate in Living Cells.Journal of the American Chemical Society · 2024Article
- Natural variation in the pattern-triggered immunity response in plants: Investigations, implications and applications.Molecular plant pathology · 2024Review
- Editorial for the Special Issue on Flexible Sensors and Actuators for Biomedicine.Micromachines · 2023Article
- Red-shifted activity-based sensors for ethyleneRSC chemical biology · 2023Article
- The design of synthetic gene circuits in plants: new components, old challenges.Journal of experimental botany · 2023Review
- Basis for high-affinity ethylene binding by the ethylene receptor ETR1 of Arabidopsis.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Detection of Ethylene with Defined Metal Complexes: Strategies and Recent Advances.Analysis & sensing · 2023Article
- Plant Hormonomics: A Key Tool for Deep Physiological Phenotyping to Improve Crop Productivity.Plant & cell physiology · 2023Review
- Review on Nanoparticles and Nanostructured Materials: Bioimaging, Biosensing, Drug Delivery, Tissue Engineering, Antimicrobial, and Agro-Food Applications.Nanomaterials (Basel, Switzerland) · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Enzyme biosensors are useful tools that can monitor rapid changes in metabolite levels in real-time. However, current approaches are largely constrained to metabolites within a limited chemical space. With the rising development of artificial metalloenzymes (ArM), a unique opportunity exists to design biosensors from the ground-up for metabolites that are difficult to detect using current technologies. Here we present the design and development of the ArM ethylene probe (AEP), where an albumin scaffold is used to solubilize and protect a quenched ruthenium catalyst. In the presence of the phytohormone ethylene, cross metathesis can occur to produce fluorescence. The probe can be used to detect both exogenous- and endogenous-induced changes to ethylene biosynthesis in fruits and leaves. Overall, this work represents an example of an ArM biosensor, designed specifically for the spatial and temporal detection of a biological metabolite previously not accessible using enzyme biosensors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.