Evidence map›Paper›PMID 31848334›Full record

ArticleNature communications2019

Wireless, battery-free, fully implantable multimodal and multisite pacemakers for applications in small animal models.

Philipp Gutruf, Rose T Yin, K Benjamin Lee, Jokubas Ausra, Jaclyn A Brennan, Yun Qiao, Zhaoqian Xie, Roberto Peralta, Olivia Talarico, Alejandro Murillo and 10 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 98 papers.

0numbers the graph read from it
0cells of the map it votes in
98citing papers in PubMed
11.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

98 citing papers in PubMed, 216 citations in OpenAlex.

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  16. Multifunctional bioelectronics for brain-body circuits.Nature reviews bioengineering · 2025
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38 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 4 institutions in 2 countries.

Philipp GutrufDepartment of Biomedical Engineering, University of Arizona, Tucson, AZ, 85721, USA. pgutruf@email.arizona.edu.ORCID http://orcid.org/0000-0002-7183-7268
Rose T YinDepartment of Biomedical Engineering, The George Washington University, Washington, DC, USA.
K Benjamin LeeDepartment of Biomedical Engineering, The George Washington University, Washington, DC, USA.
Jokubas AusraDepartment of Biomedical Engineering, University of Arizona, Tucson, AZ, 85721, USA.ORCID http://orcid.org/0000-0002-4860-6197
Jaclyn A BrennanDepartment of Biomedical Engineering, The George Washington University, Washington, DC, USA.
Yun QiaoDepartment of Biomedical Engineering, The George Washington University, Washington, DC, USA.
Zhaoqian XieDepartment of Engineering Mechanics, Dalian University of Technology, Dalian, 116024, China.ORCID http://orcid.org/0000-0003-1320-817X
Roberto PeraltaDepartment of Aerospace and Mechanical Engineering, University of Arizona, Tucson, AZ, 85721, USA.ORCID http://orcid.org/0000-0003-3429-7466
Olivia TalaricoDepartment of Biomedical Engineering, University of Arizona, Tucson, AZ, 85721, USA.
Alejandro MurilloDepartment of Biomedical Engineering, The George Washington University, Washington, DC, USA.
Sheena W ChenDepartment of Biomedical Engineering, The George Washington University, Washington, DC, USA.
John P LeshockDepartment of Biomedical Engineering, McCormick School of Engineering and Applied Science, Northwestern University, Evanston, IL, USA.
Chad R HaneyCenter for Advanced Molecular Imaging, Radiology, and Biomedical Engineering, Northwestern University, Evanston, IL, USA.ORCID http://orcid.org/0000-0001-5981-2925
Emily A WatersCenter for Advanced Molecular Imaging, Northwestern University, Evanston, IL, USA.ORCID http://orcid.org/0000-0003-3479-6054
Changxing ZhangAML, Department of Engineering Mechanics, Interdisciplinary Research Center for Flexible Electronics Technology, Tsinghua University, Beijing, 100084, China.
Haiwen LuanDepartment of Civil and Environmental Engineering, Mechanical Engineering, and Materials Science and Engineering, Northwestern University, Evanston, IL, 60208, USA.
Yonggang HuangDepartment of Civil and Environmental Engineering, Mechanical Engineering, and Materials Science and Engineering, Northwestern University, Evanston, IL, 60208, USA.ORCID http://orcid.org/0000-0002-0483-8359
Gregory TrachiotisDC Veterans Affairs Medical Center, The George Washington University, Washington, DC, USA.
Igor R EfimovDepartment of Biomedical Engineering, The George Washington University, Washington, DC, USA. efimov@email.gwu.edu.ORCID http://orcid.org/0000-0002-1483-5039
John A RogersDepartments of Materials Science and Engineering, Biomedical Engineering, Neurological Surgery, Chemistry, Mechanical Engineering, Electrical Engineering and Computer Science, Simpson Querrey Institute and Feinberg Medical School, Center for Bio-Integrated Electronics, Northwestern University, Evanston, IL, 60208, USA. jrogers@northwestern.edu.ORCID http://orcid.org/0000-0002-2980-3961
George Washington University · USNorthwestern University · USUniversity of Arizona · USTsinghua University · CN

Funding

Cardiovascular Biomedical Engineering Training GrantT32HL007955 · NHLBI · UNIVERSITY OF ARIZONA · PI BARTON, JENNIFER KEHLET · 2001 to 2020
$5.1M
6 · The paper itself

Abstract

Small animals support a wide range of pathological phenotypes and genotypes as versatile, affordable models for pathogenesis of cardiovascular diseases and for exploration of strategies in electrotherapy, gene therapy, and optogenetics. Pacing tools in such contexts are currently limited to tethered embodiments that constrain animal behaviors and experimental designs. Here, we introduce a highly miniaturized wireless energy-harvesting and digital communication electronics for thin, miniaturized pacing platforms weighing 110 mg with capabilities for subdermal implantation and tolerance to over 200,000 multiaxial cycles of strain without degradation in electrical or optical performance. Multimodal and multisite pacing in ex vivo and in vivo studies over many days demonstrate chronic stability and excellent biocompatibility. Optogenetic stimulation of cardiac cycles with in-animal control and induction of heart failure through chronic pacing serve as examples of modes of operation relevant to fundamental and applied cardiovascular research and biomedical technology.

Indexed as

Cardiac Resynchronization Therapy DevicesMiniaturizationAnimalsBiomedical EngineeringDisease Models, AnimalElectric Power SuppliesFemaleHeart FailureHumansIsolated Heart PreparationMaleMiceMice, TransgenicOptogeneticsWireless Technology

Identifiers

PMID31848334
PMCPMC6917818
OpenAlexW2994858181

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.