Evidence map›Paper›PMID 31848294›Full record

Trial reportJournal of the American Society of Nephrology : JASN2020

A Randomized Trial Comparing the Safety, Adherence, and Pharmacodynamics Profiles of Two Doses of Sodium Bicarbonate in CKD: the BASE Pilot Trial.

Kalani L Raphael, Tamara Isakova, Joachim H Ix, Dominic S Raj, Myles Wolf, Linda F Fried, Jennifer J Gassman, Cynthia Kendrick, Brett Larive, Michael F Flessner and 8 more

Open access · greenAbstract readComparative StudyMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of the American Society of Nephrology : JASN, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 1 pooled it
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Trial
  5. Trial
  6. Trial
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Review
  16. Article
  17. Metabolic acidosis in chronic kidney disease: mere consequence or also culprit?Pflugers Archiv : European journal of physiology · 2024
    Review
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors at 13 institutions in 1 country.

Kalani L RaphaelDepartment of Internal Medicine, University of Utah Health and Renal Section, Veterans Affairs Salt Lake City Health Care System, Salt Lake City, Utah; kalani.raphael@hsc.utah.edu.ORCID 0000-0002-1378-2609
Tamara IsakovaDepartment of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.
Joachim H IxDepartment of Medicine, University of California San Diego and Renal Section, Veterans Affairs San Diego Healthcare System, San Diego, California.
Dominic S RajDivision of Renal Diseases and Hypertension, Department of Medicine, George Washington University School of Medicine, Washington, DC.
Myles WolfDivision of Nephrology, Department of Medicine, Duke Clinical Research Institute, Duke University, Durham, North Carolina.
Linda F FriedDepartment of Medicine, University of Pittsburgh and Renal Section, Veterans Affairs Pittsburgh Health Care System, Pittsburgh, Pennsylvania.
Jennifer J GassmanDepartment of Quantitative Health Sciences, Cleveland Clinic Foundation, Cleveland, Ohio.
Cynthia KendrickDepartment of Quantitative Health Sciences, Cleveland Clinic Foundation, Cleveland, Ohio.
Brett LariveDepartment of Quantitative Health Sciences, Cleveland Clinic Foundation, Cleveland, Ohio.
Michael F FlessnerDivision of Kidney, Urologic, and Hematologic Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland.
Susan R MendleyDivision of Kidney, Urologic, and Hematologic Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland.
Thomas H HostetterDepartment of Medicine, Case Western Reserve Hospitals, Cleveland, Ohio.
Geoffrey A BlockDenver Nephrology, Denver, Colorado.
Ping LiRenal Section, Veterans Affairs Washington, DC Health Care System, Washington, DC.
John P MiddletonDivision of Nephrology, Department of Medicine, Duke Clinical Research Institute, Duke University, Durham, North Carolina.
Stuart M SpragueDepartment of Medicine, Northshore University Health System, University of Chicago, Evanston, Illinois; and.ORCID 0000-0002-3330-0179
Donald E WessonHealth and Wellness Center, Baylor Scott & White Health, Dallas, Texas.
Alfred K CheungDepartment of Internal Medicine, University of Utah Health and Renal Section, Veterans Affairs Salt Lake City Health Care System, Salt Lake City, Utah.
Cleveland Clinic · USDuke University · USNational Institutes of Health · USUniversity of Utah · USBaylor Scott & White Health · USColorado Kidney Care · USGeorge Washington University · USNorthShore University HealthSystem · USNorthwestern University · USOffice of Patient Care Services · USUniversity of California San Diego · USUniversity of Pittsburgh · USWestern Reserve Hospital · US

Funding

Data Coordinating Center for Pilot Studies of Candidate Therapies for CKDU01DK099877 · NIDDK · CLEVELAND CLINIC LERNER COM-CWRU · PI GASSMAN, JENNIFER J · 2013 to 2018
$5.5M
Impact of phosphate and FGF23 reduction on intermediate end points in CKDR01DK102438 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI ISAKOVA, TAMARA · 2014 to 2018
$3.0M
A Novel Approach to Phosphorus Lowering in Patients with Chronic Kidney DiseaseU01DK097093 · NIDDK · VETERANS MEDICAL RESEARCH FDN/SAN DIEGO · PI IX, JOACHIM H · 2013 to 2017
$2.5M
Pilot Studies Targeting Mineral Metabolism in CKDU01DK099930 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI ISAKOVA, TAMARA · 2013 to 2018
$1.8M
Anti-inflammatory Therapy in Diabetic CKDU01DK099924 · NIDDK · GEORGE WASHINGTON UNIVERSITY · PI RAJ, DOMINIC S · 2013 to 2018
$1.8M
Oral Sodium Bicarbonate to Slow Chronic Kidney Disease ProgressionU01DK099933 · NIDDK · UNIVERSITY OF UTAH · PI CHEUNG, ALFRED K, RAPHAEL, KALANI LUKELA · 2013 to 2018
$1.5M
NIDDK NIH HHS R01 DK102438NIDDK NIH HHS U01 DK097093NIDDK NIH HHS U01 DK099877NIDDK NIH HHS U01 DK099924NIDDK NIH HHS U01 DK099930NIDDK NIH HHS U01 DK099933
6 · The paper itself

Abstract

backgroundOral sodium bicarbonate (NaHCO

methodsThis multicenter pilot trial assessed the safety, tolerability, adherence, and pharmacodynamics of two doses of NaHCO

resultsMean±SD baseline eGFR was 36±9 ml/min per 1.73 m

conclusionsBoth NaHCO

Indexed as

Drug MonitoringAgedAged, 80 and overFemaleHumansMaleMiddle AgedPilot ProjectsRenal Insufficiency, ChronicSodium BicarbonateSodium Bicarbonatechronic kidney diseasechronic metabolic acidosisclinical nephrologyclinical trialdiabetes mellitushypertension

Identifiers

PMID31848294
PMCPMC6934992
OpenAlexW2994621179

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.