Evidence map›Paper›PMID 31848291›Full record

ArticlemBio2019

RIP1, RIP3, and MLKL Contribute to Cell Death Caused by Clostridium perfringens Enterotoxin.

Archana Shrestha, Iman Mehdizadeh Gohari, Bruce A McClane

Open access · goldAbstract read
In one paragraph

Article in mBio, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 30 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Computational and structural biotechnology journal · 2025
    Article
  6. Article
  7. The biology and pathogenicity ofMicrobiology and molecular biology reviews : MMBR · 2024
    Review
  8. Review
  9. Article
  10. Article
  11. Review
  12. CaFrontiers in cardiovascular medicine · 2022
    Article
  13. Article
  14. Article
  15. Article
  16. The potential role of necroptosis in clinical diseases (Review).International journal of molecular medicine · 2021
    Review
  17. Article
  18. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Archana ShresthaDepartment of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Iman Mehdizadeh GohariDepartment of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Bruce A McClaneDepartment of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA bamcc@pitt.edu.
University of Pittsburgh · US

Funding

MECHANISMS OF ACTION OF C PERFRINGENS EXTEROTOXINR01AI019844 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MC CLANE, BRUCE A · 1985 to 2024
$5.4M
Mechanisms of Action of C. Perfringens EnterotoxinR37AI019844 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MC CLANE, BRUCE A · 2005 to 2014
$3.0M
NIAID NIH HHS R01 AI019844NIAID NIH HHS R37 AI019844
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AnimalsApoptosisCaco-2 CellsChlorocebus aethiopsClostridium InfectionsClostridium perfringensEnterotoxinsHost-Pathogen InteractionsHumansModels, BiologicalNuclear Pore Complex ProteinsProtein KinasesProtein MultimerizationReceptor-Interacting Protein Serine-Threonine KinasesRNA-Binding ProteinsVero CellsAGFG1 protein, humanenterotoxin, ClostridiumEnterotoxinsMLKL protein, humanNuclear Pore Complex ProteinsProtein KinasesReceptor-Interacting Protein Serine-Threonine KinasesRIPK3 protein, humanRNA-Binding ProteinsapoptosiscalpainClostridium perfringensClostridium perfringens enterotoxinenterotoxinMLKLnecroptosisRIP1RIP1 kinaseRIP3RIP3 kinase

Identifiers

PMID31848291
PMCPMC6918092
OpenAlexW2994647402

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.