Evidence map›Paper›PMID 31848278›Full record

ArticlemBio2019

Quantitative Visualization of Gene Expression in Mucoid and Nonmucoid Pseudomonas aeruginosa Aggregates Reveals Localized Peak Expression of Alginate in the Hypoxic Zone.

Peter Jorth, Melanie A Spero, J Livingston, Dianne K Newman

Open access · goldAbstract read
In one paragraph

Article in mBio, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
  2. Single-cell quantification of the microbiota by flow cytometry: MicFLY.bioRxiv : the preprint server for biology · 2025
    Article
  3. Review
  4. Article
  5. Targeting Anaerobic Respiration inAdvances in wound care · 2024
    Article
  6. Article
  7. Article
  8. The biogeography of infection revisited.Nature reviews. Microbiology · 2022
    Review
  9. Review
  10. Review
  11. Review
  12. Article
  13. Multiscale X-ray study ofProceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  14. Article
  15. Article
  16. Review
  17. Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Peter JorthDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, California, USA.
Melanie A SperoDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, California, USA.
J LivingstonDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, California, USA.
Dianne K NewmanDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, California, USA dkn@caltech.edu.ORCID 0000-0003-1647-1918
California Institute of Technology · US

Funding

Biological mechanisms and consequences of efficient extracellular electron transfer in Pseudomonas aeruginosaR01AI127850 · NIAID · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI Dianne K Newman · 2017 to 2026
$5.6M
Biological mechanisms and consequences of chlorate treatment on Pseudomonas aeruginosa chronic wound infectionsR21AI146987 · NIAID · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI NEWMAN, DIANNE K · 2019 to 2020
$453k
Determining mechanisms and prevalence of virulence-enhancing resistance mutationsK22AI127473 · NIAID · CEDARS-SINAI MEDICAL CENTER · PI JORTH, PETER ALLAN · 2018 to 2019
$268k
NIAID NIH HHS K22 AI127473NIAID NIH HHS R01 AI127850NIAID NIH HHS R21 AI146987
6 · The paper itself

Abstract

It is well appreciated that oxygen- and other nutrient-limiting gradients characterize microenvironments within chronic infections that foster bacterial tolerance to treatment and the immune response. However, determining how bacteria respond to these microenvironments has been limited by a lack of tools to study bacterial functions at the relevant spatial scales

Indexed as

Gene ExpressionAlginatesBiofilmsBiomarkersHumansHypoxiaIntestinal MucosaPseudomonas aeruginosaPseudomonas InfectionsAlginatesBiomarkersaggregatebiofilmsgene expressionHCRin situ hybridizationmicroscopyPseudomonas aeruginosa

Identifiers

PMID31848278
PMCPMC6918079
OpenAlexW2995223218

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.