Evidence map›Paper›PMID 31848271›Full record

ArticlemBio2019

The Aminoalkylindole BML-190 Negatively Regulates Chitosan Synthesis via the Cyclic AMP/Protein Kinase A1 Pathway in Cryptococcus neoformans.

Brian T Maybruck, Woei C Lam, Charles A Specht, Ma Xenia G Ilagan, Maureen J Donlin, Jennifer K Lodge

Open access · goldAbstract read
In one paragraph

Article in mBio, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Brian T MaybruckDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA.
Woei C LamDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA.
Charles A SpechtDepartment of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
Ma Xenia G IlaganDepartment of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, Missouri, USA.ORCID 0000-0003-2888-4859
Maureen J DonlinDepartment of Biochemistry and Molecular Biology, Saint Louis University, St. Louis, Missouri, USA.
Jennifer K LodgeDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA lodgejk@wustl.edu.
Washington University in St. Louis · USSaint Louis University · USUniversity of Massachusetts Chan Medical School · US

Funding

Preclinical studies of a Cryptococcus vaccine for AIDS patientsR01AI125045 · NIAID · WASHINGTON UNIVERSITY · PI LEVITZ, STUART MICHAEL, LODGE, JENNIFER K. · 2016 to 2025
$7.1M
Chitosan in CryptococcusR01AI072195 · NIAID · WASHINGTON UNIVERSITY · PI LODGE, JENNIFER K. · 2008 to 2018
$3.5M
ROLE OF CELL WALL INTEGRITY IN ECHINOCANDIN RESISTANCE IN C. NEOFORMANSR01AI123407 · NIAID · WASHINGTON UNIVERSITY · PI DONLIN, MAUREEN J, LODGE, JENNIFER K. · 2017 to 2021
$1.9M
NIAID NIH HHS R01 AI072195NIAID NIH HHS R01 AI123407NIAID NIH HHS R01 AI125045
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Models, BiologicalChemical PhenomenaChitosanCryptococcus neoformansCyclic AMPCyclic AMP-Dependent Protein KinasesDrug DiscoveryIndomethacinMolecular StructureMorpholinesReceptors, G-Protein-CoupledSignal TransductionChitosanCyclic AMPCyclic AMP-Dependent Protein KinasesIndomethacinindomethacin morpholinylamideMorpholinesReceptors, G-Protein-CoupledcAMPchitosanCryptococcus neoformansdrug screeningflow cytometry

Identifiers

PMID31848271
PMCPMC6918072
OpenAlexW2996290784

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.