Evidence map›Paper›PMID 31848257›Full record

ArticleNeurology2020

Cognitive correlates of cerebellar resting-state functional connectivity in Parkinson disease.

Baijayanta Maiti, Jonathan M Koller, Abraham Z Snyder, Aaron B Tanenbaum, Scott A Norris, Meghan C Campbell, Joel S Perlmutter

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07024875 (Precision Neuroimaging of Parkinson's Disease), which is not on this map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07024875 recruitingnot on this mapstarted 2025, after this paper: background citation

Precision Neuroimaging of Parkinson's Disease

Typeobservational_patient_registrySponsorWashington University School of MedicineRan2025 to 2031Enrolled120ConditionsParkinsons Disease (PD)
3 · Its place in the literature

Who cites it

31 citing papers in PubMed.

  1. Article
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  6. Brain network pathophysiology in dystonia.Dystonia (Lausanne, Switzerland) · 2025
    Article
  7. Review
  8. Investigation of total cerebellar and flocculonodular lobe volume in Parkinson's disease and healthy individuals: a brain segmentation study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024
    Article
  9. Review
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  11. Review
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  15. Abnormal cerebellum connectivity patterns related to motor subtypes of Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996) · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Baijayanta MaitiFrom the Departments of Neurology (B.M., A.Z.S., A.T., A.B.T., S.A.N., M.C.C., J.S.P.), Radiology (A.Z.S., S.A.N., M.C.C., J.S.P), Psychiatry (J.M.K), and Neuroscience (J.S.P.) and Programs in Occupational Therapy (J.S.P.) and Physical Therapy (J.S.P.), Washington University School of Medicine, St. Louis, MO.ORCID 0000-0002-2583-4947
Jonathan M KollerFrom the Departments of Neurology (B.M., A.Z.S., A.T., A.B.T., S.A.N., M.C.C., J.S.P.), Radiology (A.Z.S., S.A.N., M.C.C., J.S.P), Psychiatry (J.M.K), and Neuroscience (J.S.P.) and Programs in Occupational Therapy (J.S.P.) and Physical Therapy (J.S.P.), Washington University School of Medicine, St. Louis, MO.ORCID 0000-0002-1409-5608
Abraham Z SnyderFrom the Departments of Neurology (B.M., A.Z.S., A.T., A.B.T., S.A.N., M.C.C., J.S.P.), Radiology (A.Z.S., S.A.N., M.C.C., J.S.P), Psychiatry (J.M.K), and Neuroscience (J.S.P.) and Programs in Occupational Therapy (J.S.P.) and Physical Therapy (J.S.P.), Washington University School of Medicine, St. Louis, MO.
Aaron B TanenbaumFrom the Departments of Neurology (B.M., A.Z.S., A.T., A.B.T., S.A.N., M.C.C., J.S.P.), Radiology (A.Z.S., S.A.N., M.C.C., J.S.P), Psychiatry (J.M.K), and Neuroscience (J.S.P.) and Programs in Occupational Therapy (J.S.P.) and Physical Therapy (J.S.P.), Washington University School of Medicine, St. Louis, MO.
Scott A NorrisFrom the Departments of Neurology (B.M., A.Z.S., A.T., A.B.T., S.A.N., M.C.C., J.S.P.), Radiology (A.Z.S., S.A.N., M.C.C., J.S.P), Psychiatry (J.M.K), and Neuroscience (J.S.P.) and Programs in Occupational Therapy (J.S.P.) and Physical Therapy (J.S.P.), Washington University School of Medicine, St. Louis, MO.
Meghan C CampbellFrom the Departments of Neurology (B.M., A.Z.S., A.T., A.B.T., S.A.N., M.C.C., J.S.P.), Radiology (A.Z.S., S.A.N., M.C.C., J.S.P), Psychiatry (J.M.K), and Neuroscience (J.S.P.) and Programs in Occupational Therapy (J.S.P.) and Physical Therapy (J.S.P.), Washington University School of Medicine, St. Louis, MO.
Joel S PerlmutterFrom the Departments of Neurology (B.M., A.Z.S., A.T., A.B.T., S.A.N., M.C.C., J.S.P.), Radiology (A.Z.S., S.A.N., M.C.C., J.S.P), Psychiatry (J.M.K), and Neuroscience (J.S.P.) and Programs in Occupational Therapy (J.S.P.) and Physical Therapy (J.S.P.), Washington University School of Medicine, St. Louis, MO. joel@npg.wustl.edu.

Funding

INVESTIGATIONS OF DEMENTIA IN PARKINSON DISEASER01NS075321 · NINDS · WASHINGTON UNIVERSITY · PI CAMPBELL, MEGHAN C, PERLMUTTER, JOEL SYNES · 2011 to 2021
$8.2M
Parkinson Disease Clinical Subtypes: Validation, Clinical Utility, and Biological CorrelatesR01NS097437 · NINDS · WASHINGTON UNIVERSITY · PI MEGHAN C CAMPBELL · 2017 to 2026
$4.1M
NINDS CENTER CORE FOR BRAIN IMAGINGP30NS098577 · NINDS · WASHINGTON UNIVERSITY · PI AN, HONGYU · 2016 to 2019
$2.4M
Investigations of Dementia in Parkinson DiseaseRF1NS075321 · NINDS · WASHINGTON UNIVERSITY · PI CAMPBELL, MEGHAN C, PERLMUTTER, JOEL SYNES · 2023 to 2023
$2.3M
RES FACIL CONST: NEUROSCIENCE: LANGUAGE, COGNITION &BEHAVIOR, PAIN, DEPRESSIONC06RR020092 · NCRR · WASHINGTON UNIVERSITY · PI STANLEY, SAMUEL · 2004 to 2004
$1.6M
NCRR NIH HHS C06 RR020092NINDS NIH HHS P30 NS098577NINDS NIH HHS R01 NS075321NINDS NIH HHS R01 NS097437NINDS NIH HHS RF1 NS075321
6 · The paper itself

Abstract

objectiveTo investigate in a cross-sectional study the contributions of altered cerebellar resting-state functional connectivity (FC) to cognitive impairment in Parkinson disease (PD).

methodsWe conducted morphometric and resting-state FC-MRI analyses contrasting 81 participants with PD and 43 age-matched healthy controls using rigorous quality assurance measures. To investigate the relationship of cerebellar FC to cognitive status, we compared participants with PD without cognitive impairment (Clinical Dementia Rating [CDR] scale score 0, n = 47) to participants with PD with impaired cognition (CDR score ≥0.5, n = 34). Comprehensive measures of cognition across the 5 cognitive domains were assessed for behavioral correlations.

resultsThe participants with PD had significantly weaker FC between the vermis and peristriate visual association cortex compared to controls, and the strength of this FC correlated with visuospatial function and global cognition. In contrast, weaker FC between the vermis and dorsolateral prefrontal cortex was found in the cognitively impaired PD group compared to participants with PD without cognitive impairment. This effect correlated with deficits in attention, executive functions, and global cognition. No group differences in cerebellar lobular volumes or regional cortical thickness of the significant cortical clusters were observed.

conclusionThese results demonstrate a correlation between cerebellar vermal FC and cognitive impairment in PD. The absence of significant atrophy in cerebellum or relevant cortical areas suggests that this could be related to local pathophysiology such as neurotransmitter dysfunction.

Indexed as

AgedCerebellumCognitive DysfunctionCross-Sectional StudiesFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedNeural PathwaysParkinson DiseaseRest

Identifiers

PMID31848257
PMCPMC7079688

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.