ArticleProceedings of the National Academy of Sciences of the United States of America2020
Imaging the effect of the circadian light-dark cycle on the glymphatic system in awake rats.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
54 citing papers in PubMed, 82 citations in OpenAlex.
- Mescaline Alters Cerebellar Function, Global Connectivity, and Frequency-Selective Acoustic Gating: A BOLD fMRI Study in Awake Rats.Neuroscience bulletin · 2026Article
- Human Cerebral Blood Flow Activity with Diurnal Variation Differentially Correlated with the Suprachiasmatic Nucleus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Glymphatic-meningeal lymphatic system imbalance: a peripheral-to-central inflammatory bridge in perioperative neurocognitive disorders.Frontiers in immunology · 2026Review
- Orchestrating brain fluid dynamics: circadian regulation of CSF, glymphatic exchange, and waste clearance.Frontiers in cell and developmental biology · 2026Review
- Variability in the circulation of cerebrospinal fluid: causes and clinical implications for intraventricular drug delivery.Frontiers in drug delivery · 2026Review
- Melatonin Mitigates Sleep Restriction-Induced Cognitive and Glymphatic Dysfunction Via Aquaporin-4 Polarization.Molecular neurobiology · 2025Article
- Multimodal Magnetic Resonance Imaging with Mild Repetitive Head Injury in Awake Rats: Modeling the Human Experience and Clinical Condition.Neuroscience bulletin · 2025Article
- Investigating glymphatic function and bed nucleus of the stria terminalis-based functional connectivity in Parkinson's disease with and without depression.NPJ Parkinson's disease · 2025Article
- Dose-dependent changes in global brain activity and functional connectivity following exposure to psilocybin: a BOLD MRI study in awake rats.Frontiers in neuroscience · 2025Article
- Advancing Hydrocephalus Management: Pathogenesis Insights, Therapeutic Innovations, and Emerging Challenges.Aging and disease · 2024Review
- Perivascular space diffusivity and brain microstructural measures are associated with circadian time and sleep quality.Journal of sleep research · 2024Article
- Glymphatic dysfunction in multiple sclerosis and its association with disease pathology and disability.Multiple sclerosis (Houndmills, Basingstoke, England) · 2024Article
- A brain-wide solute transport model of the glymphatic system.Journal of the Royal Society, Interface · 2024Article
- Circadian Mechanisms in Brain Fluid Biology.Circulation research · 2024Review
- Diurnal Variation of Brain Activity in the Human Suprachiasmatic Nucleus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Glymphatic system dysfunction in recovered patients with mild COVID-19: A DTI-ALPS study.iScience · 2024Article
- A circadian clock regulates the blood-brain barrier across phylogeny.Vitamins and hormones · 2024Review
- Influencing factors of glymphatic system during perioperative period.Frontiers in neuroscience · 2024Review
- Exploring Astrocyte-Mediated Mechanisms in Sleep Disorders and Comorbidity.Biomedicines · 2023Review
- Intrathecal [Scientific reports · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
The glymphatic system functions in the removal of potentially harmful metabolites and proteins from the brain. Dynamic, contrast-enhanced MRI was used in fully awake rats to follow the redistribution of intraventricular contrast agent entrained to the light-dark cycle and its hypothetical relationship to the sleep-waking cycle, blood flow, and brain temperature in specific brain areas. Brain areas involved in circadian timing and sleep-wake rhythms showed the lowest redistribution of contrast agent during the light phase or time of inactivity and sleep in rats. Global brain redistribution of contrast agent was heterogeneous. The redistribution was highest along the dorsal cerebrum and lowest in the midbrain/pons and along the ventral surface of the brain. This heterogeneous redistribution of contrast agent paralleled the gradients and regional variations in brain temperatures reported in the literature for awake animals. Three-dimensional quantitative ultrashort time-to-echo contrast-enhanced imaging was used to reconstruct small, medium, and large arteries and veins in the rat brain and revealed areas of lowest redistribution overlapped with this macrovasculature. This study raises new questions and theoretical considerations of the impact of the light-dark cycle, brain temperature, and blood flow on the function of the glymphatic system.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.