ArticleJournal of neurology, neurosurgery, and psychiatry2020
Risk of spread in adult-onset isolated focal dystonia: a prospective international cohort study.
Article in Journal of neurology, neurosurgery, and psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
48 citing papers in PubMed, 79 citations in OpenAlex.
- Segmental and Multifocal Isolated Dystonias: Similarities and Differences.Movement disorders clinical practice · 2026Article
- Cervical spondylotic myelopathy caused by cervical dystonia: a case report.Acta neurologica Belgica · 2026Article
- Preferential age-related striatal volume preservation in cervical dystonia.Journal of neurology · 2026Article
- Clinical Presentation and Evolution of Isolated Focal and Segmental Dystonia in Adults - 20 Years' Experience from a Botulinum Toxin Clinic.Annals of Indian Academy of Neurology · 2026Article
- Deep brain stimulation for pediatric dystonia under general anesthesia with endotracheal intubation: case series in a tertiary hospital.Frontiers in pediatrics · 2026Article
- The relationship between occupation and specific forms of idiopathic adult-onset dystonia.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Article
- Development of a Patient-Centered Outcome Tool for Blepharospasm: A Stepwise Modified Delphi Study.Toxins · 2025Article
- Smartphone video-based early diagnosis of blepharospasm using dual cross-attention modeling enhanced by facial pose estimation.NPJ digital medicine · 2025Article
- Comparative study of brain activity and functional connectivity in blepharospasm and blepharospasm-oromandibular dystonia.Frontiers in neurology · 2025Article
- Lesion-Induced Blepharospasm: Epidemiology and Clinical Characteristics.Tremor and other hyperkinetic movements (New York, N.Y.) · 2025Article
- Oromandibular dystonia: from onset to spread a multicenter italian study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Article
- Blood-Based Proteomics for Adult-Onset Focal Dystonias.Annals of neurology · 2024Article
- Can symptoms or signs of cervical dystonia occur without abnormal movements of the head or neck?Parkinsonism & related disorders · 2024Article
- Article
- Demographics and Clinical Characteristics Associated with the Spread of New-Onset Laryngeal Dystonia.The Laryngoscope · 2024Article
- Sensitization-Associated Symptoms and Neuropathic-like Features in Patients with Cervical Dystonia and Pain.Journal of clinical medicine · 2024Article
- Genetic Update and Treatment for Dystonia.International journal of molecular sciences · 2024Review
- Risk of Spreading in Adult-onset Dystonia.Tremor and other hyperkinetic movements (New York, N.Y.) · 2024Article
- Clinical and physiological characteristics of tremor in a large cohort of focal and segmental dystonia.Dystonia (Lausanne, Switzerland) · 2024Article
- An Empirical Comparison of Commonly Used Universal Rating Scales for Dystonia.Movement disorders clinical practice · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
20 authors at 11 institutions in 3 countries.
Funding
Abstract
objectiveIsolated focal dystonia can spread to muscles beyond the initially affected body region, but risk of spread has not been evaluated in a prospective manner. Furthermore, body regions at risk for spread and the clinical factors associated with spread risk are not well characterised. We sought here to prospectively characterise risk of spread in recently diagnosed adult-onset isolated focal dystonia patients.
methodsPatients enrolled in the Dystonia Coalition with isolated dystonia affecting only the neck, upper face, hand or larynx at onset of symptoms were included. Timing of follow-up visits was based on a sliding scale depending on symptom onset and ranged from 1 to 4 years. Descriptive statistics, Kaplan-Meier survival curves and Cox proportional hazard regression models were used to assess clinical characteristics associated with dystonia spread.
results487 enrolled participants (68.3% women; mean age: 55.6±12.2 years) met our inclusion/exclusion criteria. Spread was observed in 50% of blepharospasm, 8% of cervical dystonia, 17% of hand dystonia and 16% of laryngeal dystonia cases. Most common regions for first spread were the oromandibular region (42.2%) and neck (22.4%) for blepharospasm, hand (3.5%) for cervical dystonia and neck for hand (12.8%) and laryngeal (15.8%) dystonia. Increased spread risk was associated with a positive family history (HR=2.18, p=0.012) and self-reported alcohol responsiveness (HR=2.59, p=0.009).
conclusionsInitial body region affected in isolated focal dystonia has differential risk and patterns of spread. Genetic factors likely influence the risk of spread. These findings can aid clinical prognostication and inform future investigations into potential disease-modifying treatments.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.