Evidence map›Paper›PMID 31848212›Full record

ArticleGenome research2020

Heterodimerization of TFAP2 pioneer factors drives epigenomic remodeling during neural crest specification.

Megan Rothstein, Marcos Simoes-Costa

Open access · bronzeAbstract read
In one paragraph

Article in Genome research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers.

0numbers the graph read from it
0cells of the map it votes in
83citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

83 citing papers in PubMed, 115 citations in OpenAlex.

  1. Review
  2. The lipid raft-linker gene Raftlin-2 is expressed in migrating neural crest cells.Differentiation; research in biological diversity · 2026
    Article
  3. Article
  4. TFAP2A links drug resistance to antitumor immunity.bioRxiv : the preprint server for biology · 2026
    Article
  5. Article
  6. Regulatory logic underlying neural crest contributions to the head versus the heart.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Ectomesenchymal identity emerges via relief ofbioRxiv : the preprint server for biology · 2025
    Article
  19. Article
  20. Article

23 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Megan RothsteinDepartment of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14850, USA.
Marcos Simoes-CostaDepartment of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14850, USA.
Cornell University · US

Funding

Genomic control of neural crest identity by signaling systemsR01DE028576 · NIDCR · CORNELL UNIVERSITY · PI SIMOES-COSTA, MARCOS · 2019 to 2023
$1.9M
Integrating signaling and transcriptional control in neural crest specificationR00DE024232 · NIDCR · CORNELL UNIVERSITY · PI SIMOES-COSTA, MARCOS · 2017 to 2019
$747k
A Tfap2-mediated molecular switch for neural crest induction and specificationF31HD097927 · NICHD · CORNELL UNIVERSITY · PI ROTHSTEIN, MEGAN · 2019 to 2021
$94k
NICHD NIH HHS F31 HD097927NIDCR NIH HHS R00 DE024232NIDCR NIH HHS R01 DE028576
6 · The paper itself

Abstract

Cell fate commitment involves the progressive restriction of developmental potential. Recent studies have shown that this process requires not only shifts in gene expression but also an extensive remodeling of the epigenomic landscape. To examine how chromatin states are reorganized during cellular specification in an in vivo system, we examined the function of pioneer factor

Indexed as

Epigenesis, GeneticProtein MultimerizationAnimalsCell DifferentiationChick EmbryoEmbryonic DevelopmentEpigenomicsFluorescent Antibody TechniqueGene Expression Regulation, DevelopmentalImmunohistochemistryNeural CrestRegulatory Sequences, Nucleic AcidTranscription Factor AP-2Transcription Factor AP-2

Identifiers

PMID31848212
PMCPMC6961570
OpenAlexW2996705374

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.