Evidence map›Paper›PMID 31848139›Full record

ArticleBMJ case reports2019

Chylothorax: complication attributed to dasatinib use.

Abdullah Al-Abcha, Mian Harris Iftikhar, Fawzi Abu Rous, Heather Laird-Fick

Open access · greenAbstract readCase Reports
In one paragraph

Article in BMJ case reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.5field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Dasatinib-Induced Chylothorax Beyond 5 Years of Treatment: Is There Actually Any Limit?European journal of case reports in internal medicine · 2023
    Article
  10. Article
  11. Brief Report: Chylothorax and Chylous Ascites During RET Tyrosine Kinase Inhibitor Therapy.Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer · 2022
    Article
  12. Article
  13. A Dasatinib-Induced Chylothorax Persisting After the Discontinuation of Dasatinib.European journal of case reports in internal medicine · 2022
    Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Abdullah Al-AbchaInternal Medicine, Michigan State University, East Lansing, Michigan, USA alabchaa@msu.edu.
Mian Harris IftikharSleep Medicine, Washington University, St Louis, Missouri, USA.
Fawzi Abu RousInternal Medicine, Michigan State University, East Lansing, Michigan, USA.
Heather Laird-FickInternal Medicine, Michigan State University, East Lansing, Michigan, USA.
Michigan State University · USWashington University in St. Louis · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A 63-year-old woman with a medical history of chronic myelogenous leukaemia treated with dasatinib, chronic obstructive pulmonary disease and heart failure with preserved ejection fraction presented with difficulty in breathing. Chest X-ray showed large right-sided pleural effusion, which was confirmed on a CT angiogram of the chest. Echocardiogram showed an ejection fraction of 61% with moderate to severely dilated right ventricle and right ventricular systolic pressure of 60 mm Hg. Diagnostic and therapeutic thoracentesis was performed, and 2.2 L of pleural fluid was removed. Pleural fluid analysis was consistent with chylothorax. Significant symptomatic improvement was noted after thoracentesis. In the absence of an alternate explanation, chylothorax was attributed to dasatinib, which was switched to nilotinib. This resulted in resolution of her pleural effusions.

Indexed as

ChylothoraxComputed Tomography AngiographyDasatinibFemaleHeart FailureHumansLeukemia, Myelogenous, Chronic, BCR-ABL PositiveMiddle AgedPulmonary Disease, Chronic ObstructiveThoracentesisTreatment OutcomeDasatinibdasatinibhaematology (drugs and medicines)respiratory medicineunwanted effects / adverse reactions

Identifiers

PMID31848139
PMCPMC6936595
OpenAlexW2995091265

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.