Evidence map›Paper›PMID 31847914›Full record

ArticleTrials2019

Evaluation of evening versus morning levothyroxine intake in elderly (MONIALE).

Karina Giassi, Vanessa Piccoli, Ticiana da Costa Rodrigues, Renato Gorga Bandeira de Mello

Registry-linked trialOpen access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Trials, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03614988 (Comparative Evaluation of Evening Versus Morning Levothyroxine Administration in Treatment of Hypothyroidism in Elderly), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03614988 naunknown statusnot on this map

Comparative Evaluation of Evening Versus Morning Levothyroxine Administration in Treatment of Hypothyroidism in Elderly

TypeinterventionalSponsorHospital de Clinicas de Porto AlegreRan2018 to 2020Enrolled208ConditionsAging, Primary Hypothyroidism, Interaction Drug FoodArmsEvening Levothyroxine Administration, Morning Levothyroxine Administration
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Circadian Variation in Efficacy of Medications.Clinical pharmacology and therapeutics · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Karina GiassiEndocrinology Program, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
Vanessa PiccoliInternal Medicine and Geriatric Division, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.
Ticiana da Costa RodriguesEndocrinology Program, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
Renato Gorga Bandeira de MelloEndocrinology Program, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil. rgmello@hcpa.edu.br.ORCID http://orcid.org/0000-0003-4944-0085
Universidade Federal do Rio Grande do Sul · BRHospital de Clínicas de Porto Alegre · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe aging population is associated with increased multimorbidity and polypharmacy. Older adults are at a higher risk of adverse events and reduced therapeutic response. This phenomenon is partially explained by drug interactions and treatment adherence. Most randomized clinical trials have found no significant differences between morning and evening levothyroxine (LT METHODS/

designThis randomized crossover clinical trial will include participants aged 60 years or older with primary hypothyroidism. The trial groups will consist of morning LT DISCUSSION: Considering the aging population, the increased prevalence of multimorbidity and polypharmacy, as well as potential drug interactions and treatment adherence difficulties, an alternative LT

trial registrationClinicalTrials.gov, NCT03614988. Registered 30 July 2018.

Indexed as

AgedAged, 80 and overBreakfastCross-Over StudiesDrug Administration ScheduleDrug InteractionsFemaleHumansHypothyroidismMaleMealsMiddle AgedRandomized Controlled Trials as TopicThyrotropinThyroxineThyrotropinThyroxineAgedHypothyroidismLevothyroxine

Identifiers

PMID31847914
PMCPMC6918562
OpenAlexW2995482327

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.