Evidence map›Paper›PMID 31847864›Full record

ArticleJournal of experimental & clinical cancer research : CR2019

Human bone marrow mesenchymal stem cells-derived microRNA-205-containing exosomes impede the progression of prostate cancer through suppression of RHPN2.

Shuangjian Jiang, Chengqiang Mo, Shengjie Guo, Jintao Zhuang, Bin Huang, Xiaopeng Mao

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of experimental & clinical cancer research : CR, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 61 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed, 1 pooled it
4.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 1 synthesis or guideline pooled it, 104 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Biology and Therapeutic Potential of Exosomes, Targeted Drug Delivery.International journal of molecular sciences · 2026
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  16. Therapeutic Applications of Stem Cell-Derived Exosomes.International journal of molecular sciences · 2024
    Review
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  18. Role of Exosomal miR-205-5p Cargo in Angiogenesis and Cell Migration.International journal of molecular sciences · 2024
    Article
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  20. Review

1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Shuangjian Jiang *Department of Urology Surgery, the First Affiliated Hospital, Sun Yat-Sen University, No. 58, Zhongshan No. 2 Road, Guangzhou, 510080, Guangdong Province, People's Republic of China.
Chengqiang Mo *Department of Urology Surgery, the First Affiliated Hospital, Sun Yat-Sen University, No. 58, Zhongshan No. 2 Road, Guangzhou, 510080, Guangdong Province, People's Republic of China.
Shengjie Guo *Department of Urology Surgery, Sun Yat-sen University Cancer Center, Guangzhou, 510060, People's Republic of China.
Jintao ZhuangDepartment of Urology Surgery, the Eastern Hospital of the First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510700, People's Republic of China.
Bin HuangDepartment of Urology Surgery, the First Affiliated Hospital, Sun Yat-Sen University, No. 58, Zhongshan No. 2 Road, Guangzhou, 510080, Guangdong Province, People's Republic of China.
Xiaopeng MaoDepartment of Urology Surgery, the First Affiliated Hospital, Sun Yat-Sen University, No. 58, Zhongshan No. 2 Road, Guangzhou, 510080, Guangdong Province, People's Republic of China. mxpzc1979@aliyun.com.
Sun Yat-sen University · CNThe First Affiliated Hospital, Sun Yat-sen University · CN

Funding

National Natural Science Foundation of China (CN) No. 81001146Science and Technology Planning Project of Guangdong Province No. 2017A020215168
6 · The paper itself

Abstract

backgroundHuman bone marrow mesenchymal stem cells (hBMSCs) are implicated in cancer initiation and metastasis, sometimes by releasing exosomes that mediate cell communication by delivering microRNAs (miRNAs). This study aimed to investigate the physiological mechanisms by which exosomal miR-205 derived from hBMSCs may modulate the growth of prostate cancer cells.

methodsMicroarray-based gene expression profiling of prostate cancer was adopted to identify differentially expressed genes and regulatory miRNAs, which identified the candidates RHPN2 and miR-205 as the study focus. Then the binding affinity between miR-205 and RHPN2 was identified using in silico analysis and luciferase activity detection. Prostate cancer cells were co-cultured with exosomes derived from hBMSCs treated with either miR-205 mimic or miR-205 inhibitor. Subsequently, prostate cancer cell proliferation, invasion, migration, and apoptosis were detected in vitro. The effects of hBMSCs-miR-205 on tumor growth were investigated in vivo.

resultsmiR-205 was downregulated, while RHPN2 was upregulated in prostate cancer cells. RHPN2 was a target of miR-205, and upregulated miR-205 inhibited prostate cancer cell proliferation, invasion, and migration and promoted apoptosis by targeting RHPN2. Next, experiments demonstrated that hBMSCs-derived exosomes carrying miR-205 contributed to repressed prostate cancer cell proliferation, invasion, and migration and enhanced apoptosis. Furthermore, in vivo assays confirmed the inhibitory effects of hBMSCs-derived exosomal miR-205 on prostate cancer.

conclusionThe hBMSCs-derived exosomal miR-205 retards prostate cancer progression by inhibiting RHPN2, suggesting that miR-205 may present a predictor and potential therapeutic target for prostate cancer.

Indexed as

Gene Expression Regulation, NeoplasticAdaptor Proteins, Signal TransducingAnimalsApoptosisBiomarkersCell MovementCell ProliferationDisease Models, AnimalExosomesGene Expression ProfilingHumansImmunophenotypingMaleMesenchymal Stem CellsMiceMicroRNAsAdaptor Proteins, Signal TransducingBiomarkersMicroRNAsMIR205, humanRHPN2 protein, humanExosomesHuman bone marrow mesenchymal stem cellsMicroRNA-205Prostate cancerRHPN2

Identifiers

PMID31847864
PMCPMC6918609
OpenAlexW2996061365

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.