Evidence map›Paper›PMID 31847848›Full record

ArticleJournal of neuroinflammation2019

Intrathecal injection of bone marrow stromal cells attenuates neuropathic pain via inhibition of P2X

Yongbo Teng, Yang Zhang, Shouwei Yue, Huanwen Chen, Yujuan Qu, Hui Wei, Xiaofeng Jia

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuroinflammation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Yongbo TengDepartment of Physical Medicine & Rehabilitation, Qilu Hospital, Medical School of Shandong University, Jinan, China.
Yang ZhangDepartment of Physical Medicine & Rehabilitation, Qilu Hospital, Medical School of Shandong University, Jinan, China.
Shouwei YueDepartment of Physical Medicine & Rehabilitation, Qilu Hospital, Medical School of Shandong University, Jinan, China. shouweiy@sdu.edu.cn.
Huanwen ChenDepartment of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD, 21201, USA.
Yujuan QuDepartment of Physical Medicine & Rehabilitation, Qilu Hospital, Medical School of Shandong University, Jinan, China.
Hui WeiDepartment of Physical Medicine & Rehabilitation, Qilu Hospital, Medical School of Shandong University, Jinan, China.
Xiaofeng JiaDepartment of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD, 21201, USA. xjia@som.umaryland.edu.ORCID http://orcid.org/0000-0003-1445-8525
Qilu Hospital of Shandong University · CNUniversity of Maryland, Baltimore · US

Funding

National Natural Science Foundation of China No. 81101453 and 81472159
6 · The paper itself

Abstract

backgroundNeuropathic pain is one of the most debilitating of all chronic pain syndromes. Intrathecal (i.t.) bone marrow stromal cell (BMSC) injections have a favorable safety profile; however, results have been inconsistent, and complete understanding of how BMSCs affect neuropathic pain remains elusive.

methodsWe evaluated the analgesic effect of BMSCs on neuropathic pain in a chronic compression of the dorsal root ganglion (CCD) model. We analyzed the effect of BMSCs on microglia reactivity and expression of purinergic receptor P2X

resultsI.t. BMSC transiently but significantly ameliorated neuropathic pain behavior (37.6% reduction for 2 days). We found no evidence of BMSC infiltration into the spinal cord parenchyma or DRGs, and we also demonstrated that intrathecal injection of BMSC-lysates provides similar relief. These findings suggest that the analgesic effects of i.t. BMSC were largely due to the release of BMSC-derived factors into the intrathecal space. Mechanistically, we found that while i.t. BMSCs did not change TRPV4 expression in DRG neurons, there was a significant reduction of P2X

conclusionAltogether, our results suggest that i.t. BMSC is an effective and safe treatment of neuropathic pain and provides novel evidence that BMSC's analgesic effects are largely mediated by the release of BMSC-derived factors resulting in microglial P2X

Indexed as

AnimalsInjections, SpinalMaleMesenchymal Stem CellsMesenchymal Stem Cell TransplantationMicrogliaNeuralgiaRatsRats, WistarReceptors, Purinergic P2X4Spinal CordReceptors, Purinergic P2X4Bone marrow stromal cellsNeuropathic painP2X4RTRPV4

Identifiers

PMID31847848
PMCPMC6918679
OpenAlexW2996075491

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.