ArticleAnnals of clinical microbiology and antimicrobials2019
Extended spectrum β-lactamase producing uropathogenic Escherichia coli and the correlation of biofilm with antibiotics resistance in Nepal.
Article in Annals of clinical microbiology and antimicrobials, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 54 citations in OpenAlex.
- Unraveling Biofilm-Forming Uropathogens: Isolation and Antimicrobial Resistance Patterns at Nepal Police Hospital, Kathmandu.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2026Article
- Antimicrobial resistance in uropathogens in Nigeria: pathogen profiles, resistance burden, surveillance and stewardship considerations.Frontiers in microbiology · 2026Article
- Innovative essential oil formulations for in vitro inhibition of Biofilm-Forming Extended-Spectrum β-Lactamase-Producing Escherichia coli isolated from canine infectious diarrhea.Veterinary research communications · 2025Article
- Insights into the phylogenetic profile and virulence-associated genes of multidrug-resistant uropathogenicIJID regions · 2025Article
- Integrating computational approaches to uncover β-lactamase-associated resistance in diarrheagenic Escherichia coli from pediatric patients.Scientific reports · 2025Article
- Comparative evaluation of biofilm-forming capacity in uropathogenic and commensalFrontiers in cellular and infection microbiology · 2025Article
- Detection of Integrons inInternational journal of microbiology · 2025Article
- Antimicrobial resistance and ESBL production in uropathogenicJAC-antimicrobial resistance · 2024Review
- Modified Zhibai Dihuang pill alleviated urinary tract infection induced by extended-spectrum β-lactamasePharmaceutical biology · 2023Article
- Antimicrobial resistance and biofilm formation ofHeliyon · 2023Article
- UropathogenicMicroorganisms · 2023Review
- Effect of Essential Oil fromAntibiotics (Basel, Switzerland) · 2023Article
- Correlation of biofilm formation, virulence factors, and phylogenetic groups amongJournal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2023Review
- Antimicrobial and antioxidant activity of phenolic extracts from walnut (Journal of food science and technology · 2023Article
- Antibiofilm Activity of Sundew Species against Multidrug-ResistantInternational journal of molecular sciences · 2022Article
- Phylogenetic groups, serogroups and virulence factors of uropathogenicIranian journal of microbiology · 2022Article
- Antibacterial and antibiofilm activity of Lagotis brachystachya extract against extended-spectrum β-lactamases-producing Escherichia coli from broiler chickens.Poultry science · 2022Article
- Antibiotic Resistance, Biofilm Formation and Sub-Inhibitory Hydrogen Peroxide Stimulation in UropathogenicMicrobiology insights · 2022Article
- Prevalence and Impact of Biofilms on Bloodstream and Urinary Tract Infections: A Systematic Review and Meta-Analysis.Antibiotics (Basel, Switzerland) · 2021Article
- Mechanisms of Resistance in Gram-Negative Urinary Pathogens: From Country-Specific Molecular Insights to Global Clinical Relevance.Diagnostics (Basel, Switzerland) · 2021Review
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundUrinary tract infection (UTI) is one of the frequently diagnosed infectious diseases which is caused mainly by Escherichia coli. E. coli confers resistance against the two major classes of antibiotics due to the production of extended spectrum β-lactamase enzymes (ESBL), biofilm, etc. Biofilm produced by uropathogenic E. coli (UPEC) protects from host immune system and prevent entry of antimicrobial compounds. The main objective of this cross-sectional study was to determine the correlation of biofilm production and antibiotic resistance as well as to characterize the pgaA and pgaC genes responsible for biofilm formation among uropathogenic ESBL producing E. coli.
methodsA total of 1977 mid-stream urine samples were examined and cultured for bacterial strain identification. ESBL was detected by combined disc method following CLSI whereas biofilm formation was analyzed by semi-quantitative method. Furthermore, the pgaA and pgaC genes responsible for biofilm formation in UPEC were detected by multiplex PCR. All the statistical analyses were done via IBM SPSS Statistics 21 where Pearson's correlation test were used to determine correlation (-1 ≥ r ≤ 1).
resultsE. coli was the predominant causative agent, which accounted 159 (59.3%) of the Gram-negative bacteria, where 81 (50.9%) E. coli strains were found to be ESBL producers. In addition, 86 (54.1%) E. coli strains were found to be biofilm producers. Both the pgaA and pgaC genes were detected in 45 (93.7%) the UPEC isolates, which were both biofilm and ESBL producers. Moreover, there was a positive correlation between biofilm and ESBL production.
conclusionThe analyses presented weak positive correlation between biofilm and ESBL production in which biofilm producing UPEC harbors both pgaA and pgaC genes responsible for biofilm formation.
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