ReviewOpen biology2019
DNA damage in human skin and the capacities of natural compounds to modulate the bystander signalling.
Review in Open biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The trial behind it
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Who cites it
13 citing papers in PubMed, 29 citations in OpenAlex.
- Potential Role of Dietary Antioxidants During Skin Aging.Food science & nutrition · 2025Review
- Transposable elements contribute to tissue-specific gene regulation in humans.Genes & genomics · 2024Article
- Article
- Mechanisms of Cd-Induced Cytotoxicity in Normal Human Skin Keratinocytes: Implication for Human Health.International journal of molecular sciences · 2022Article
- Review
- Repression of the Antioxidant Pyrroloquinoline Quinone in Skin Aging Induced by Bmi-1 Deficiency.BioMed research international · 2022Article
- Anti-Glycation and Anti-Aging Properties of Resveratrol Derivatives in the in-vitro 3D Models of Human Skin.Clinical, cosmetic and investigational dermatology · 2022Article
- Recent Advances in Phenolic Metabolites and Skin Cancer.International journal of molecular sciences · 2021Review
- Antioxidant Activities and Protective Effects of Dendropachol, a New Bisbibenzyl Compound fromAntioxidants (Basel, Switzerland) · 2021Article
- DNA damage in cancer development: special implications in viral oncogenesis.American journal of cancer research · 2021Article
- Prevention by the Natural Artocarpin of Morphological and Biochemical Alterations on UVB-Induced HaCaT Cells.Oxidative medicine and cellular longevity · 2021Article
- Salacia mulbarica leaf extract mediated synthesis of silver nanoparticles for antibacterial and ct-DNA damage via releasing of reactive oxygen species.IET nanobiotechnology · 2020Article
- Photoprotective Potential of the Natural Artocarpin against In Vitro UVB-Induced Apoptosis.Oxidative medicine and cellular longevity · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human skin is a stratified organ frequently exposed to sun-generated ultraviolet radiation (UVR), which is considered one of the major factors responsible for DNA damage. Such damage can be direct, through interactions of DNA with UV photons, or indirect, mainly through enhanced production of reactive oxygen species that introduce oxidative changes to the DNA. Oxidative stress and DNA damage also associate with profound changes at the cellular and molecular level involving several cell cycle and signal transduction factors responsible for DNA repair or irreversible changes linked to ageing. Crucially, some of these factors constitute part of the signalling known for the induction of biological changes in non-irradiated, neighbouring cells and defined as the bystander effect. Network interactions with a number of natural compounds, based on their known activity towards these biomarkers in the skin, reveal the capacity to inhibit both the bystander signalling and cell cycle/DNA damage molecules while increasing expression of the anti-oxidant enzymes. Based on this information, we discuss the likely polypharmacology applications of the natural compounds and next-generation screening technologies in improving the anti-oxidant and DNA repair capacities of the skin.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.