Evidence map›Paper›PMID 31847757›Full record

ArticleJournal of the Royal Society, Interface2019

A minimal computational model for three-dimensional cell migration.

Yuansheng Cao, Elisabeth Ghabache, Yuchuan Miao, Cassandra Niman, Hiroyuki Hakozaki, Samara L Reck-Peterson, Peter N Devreotes, Wouter-Jan Rappel

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the Royal Society, Interface, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Single-cell chiral symmetry breaking under confinement.bioRxiv : the preprint server for biology · 2026
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  15. Tools for computational analysis of moving boundary problems in cellular mechanobiology.Wiley interdisciplinary reviews. Systems biology and medicine · 2020
    Review
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yuansheng CaoDepartment of Physics, University of California, San Diego, La Jolla, CA 92093, USA.
Elisabeth GhabacheDepartment of Physics, University of California, San Diego, La Jolla, CA 92093, USA.
Yuchuan MiaoDepartment of Biological Chemistry, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA.
Cassandra NimanDepartment of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
Hiroyuki HakozakiNational Center for Microscopy and Imaging Research, University of California, San Diego, La Jolla, CA 92093, USA.
Samara L Reck-PetersonDepartment of Cellular and Molecular Medicine, Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA.
Peter N DevreotesDepartment of Cell Biology, Johns Hopkins University, Baltimore, MD, USA.
Wouter-Jan RappelDepartment of Physics, University of California, San Diego, La Jolla, CA 92093, USA.

Funding

Excitable Networks in Directed Cell MigrationR35GM118177 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI Peter N Devreotes · 2016 to 2026
$12.1M
NIGMS NIH HHS R35 GM118177
6 · The paper itself

Abstract

During migration, eukaryotic cells can continuously change their three-dimensional morphology, resulting in a highly dynamic and complex process. Further complicating this process is the observation that the same cell type can rapidly switch between different modes of migration. Modelling this complexity necessitates models that are able to track deforming membranes and that can capture the intracellular dynamics responsible for changes in migration modes. Here we develop an efficient three-dimensional computational model for cell migration, which couples cell mechanics to a simple intracellular activator-inhibitor signalling system. We compare the computational results to quantitative experiments using the social amoeba

Indexed as

Models, BiologicalBiomechanical PhenomenaCell MovementDictyosteliumSignal Transductioncell migrationcomputational modellingDictyosteliummigration mode

Identifiers

PMID31847757
PMCPMC6936042

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.