Observational studyJournal of the American Heart Association2020
Prognostic Significance of Serum Cholinesterase Level in Patients With Acute Decompensated Heart Failure With Preserved Ejection Fraction: Insights From the PURSUIT-HFpEF Registry.
Observational study in Journal of the American Heart Association, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 48 citations in OpenAlex.
- Review
- Improvements of cardiac function and metabolic parameters by sodium-glucose cotransporter 2 inhibitors with no significant effects on sympathetic or parasympathetic activity in chronic heart failure.Heart and vessels · 2026Observational
- Significance of Serum Cholinesterase as a Prognostic Marker in Patients with Non-dialysis-dependent Chronic Kidney Disease.Internal medicine (Tokyo, Japan) · 2025Article
- Prognostic utility of advanced lung cancer inflammation index in heart failure with preserved ejection fraction.ESC heart failure · 2025Observational
- Construction and validation of a prediction model for 90-day readmission risk in patients with chronic heart failure.Frontiers in cardiovascular medicine · 2025Article
- Association of Serum Cholinesterase with Contrast-Associated Acute Kidney Injury and Adverse Outcomes in Percutaneous Coronary Intervention Patients.Therapeutics and clinical risk management · 2025Article
- Butyrylcholinesterase and 24 h-urinary copper excretion as compliance assessment in long-term treated Wilson's disease.Frontiers in neurology · 2025Article
- Development and validation of a multifactorial nomogram to predict 48 month mortality in decompensated heart failure.ESC heart failure · 2024Article
- β-blockers may be detrimental in frail patients with heart failure with preserved ejection fraction.Clinical research in cardiology : official journal of the German Cardiac Society · 2024Observational
- The clinical relevance of quality of life in heart failure patients with preserved ejection fraction.ESC heart failure · 2023Observational
- Serum cholinesterase as a new nutritional indicator for predicting weaning failure in patients.Frontiers in medicine · 2023Article
- Pseudocholinesterase as a Biomarker for Untreated Wilson's Disease.Biomolecules · 2022Article
- Cholinesterase Deficiency Syndrome-A Pitfall in the Use of Butyrylcholinesterase as a Biomarker for Wilson's Disease.Biomolecules · 2022Article
- Time-dependent effects of storage at -80 °C on the stability of butyrylcholinesterase activity in human serum.Practical laboratory medicine · 2022Article
- Adult patients with allied disorders of Hirschsprung's disease in emergency department: An 11-year retrospective study.World journal of gastrointestinal surgery · 2022Article
- The impact of low serum cholinesterase levels on survival in patients with colorectal cancer.International journal of colorectal disease · 2022Article
- Prognostic significance of serum chloride level in heart failure patients with preserved ejection fraction.ESC heart failure · 2022Observational
- Prognostic value of nutritional parameters in systolic heart failure with renal dysfunction.PloS one · 2022Article
- Impact of admission hyperglycaemia on clinical outcomes in non-diabetic heart failure with preserved ejection fraction.ESC heart failure · 2021Observational
- Prognostic impact of Clinical Frailty Scale in patients with heart failure with preserved ejection fraction.ESC heart failure · 2021Observational
Corrections and comments
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Authors and funding
14 authors at 9 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background Malnutrition is one of the most important comorbidities in patients with heart failure with preserved ejection fraction. We recently reported the prognostic significance of serum cholinesterase level and superior predictive power of cholinesterase level to other objective nutritional indices such as the controlling nutritional status score, prognostic nutritional index, and geriatric nutritional risk index in patients with acute decompensated heart failure. The aim of this study was to clarify the prognostic role of cholinesterase in patients with heart failure with preserved ejection fraction/acute decompensated heart failure and investigate incremental cholinesterase value. Methods and Results We prospectively studied 274 consecutive patients from the PURSUIT-HFpEF (Prospective Multicenter Observational Study of Patients with Heart Failure With Preserved Ejection Fraction) study. During a follow-up period of 1.2±0.6 years, 56 patients reached the composite end points (cardiovascular death and readmission for worsening heart failure). In the multivariable Cox analysis, cholinesterase level was significantly associated with the composite end points after adjustment for major confounders. A Kaplan-Meier analysis revealed that patients with low cholinesterase levels (stratified by tertile) had significantly greater risk of reaching the composite end points than those with middle or high cholinesterase levels (
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