ArticleAntibiotics (Basel, Switzerland)2019
Development, Validation, and Stability Assessment Application of RP-HPLC-DAD Method for Quantification of Ampicillin in Total Parenteral Nutrition Admixtures.
Article in Antibiotics (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Admixture Compatibility Studies in Parenteral Formulations: Packaging, Device, and Regulatory Perspectives.AAPS PharmSciTech · 2026Review
- APTES-Modified SBA-15 as a Non-Toxic Carrier for Phenylbutazone.Materials (Basel, Switzerland) · 2022Article
- Stability and Compatibility Aspects of Drugs: The Case of Selected Cephalosporins.Antibiotics (Basel, Switzerland) · 2021Article
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Authors and funding
6 authors.
Funding
Abstract
backgroundThe administration of total parenteral nutrition (TPN) is a common procedure in intensive care units, where the concomitant use of other intravenous medication is frequently needed. One of the particularly dangerous complications for neurosurgical patients is meningitis, for which high doses of ampicillin (AMP) are used. In such cases, the addition of AMP to TPN admixtures would be a desirable procedure. Thus, the AMP determination method in TPN admixture was developed and validated.
methodsAn isocratic HPLC analysis was performed on a LiChrospher C18 end-capped column (250 mm, 4.6 mm, 5 µm) with a C18 pre-column (LiChrospher 100, 4 mm, 5 µm). The flow rate was 1.0 mL min
resultsThe method was shown to be linear, precise, accurate, specific, and robust, and it can be used for the quantitative analysis of AMP in TPN admixtures.
conclusionsThe degradation of AMP in the TPN admixtures occurred according to first order kinetics. The degradation rate was high and dependent on the composition of the mixture and the storage conditions (t
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