ArticleAntioxidants (Basel, Switzerland)2019
Protective Effects of Unsaponifiable Matter from Perilla Seed Meal on UVB-induced Damages and the Underlying Mechanisms in Human Skin Fibroblasts.
Article in Antioxidants (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 32 citations in OpenAlex.
- Paeonol-Loaded Cyclodextrin/Composite Hydrogel for Enhanced Transdermal Delivery and Skin Photoaging Repair.Gels (Basel, Switzerland) · 2026Article
- Intense pulsed light rejuvenates UVB-induced photoaging in human keratinocytes and guinea pig skin by inhibition of ERK-AP-1-MMP pathway.Scientific reports · 2026Article
- The extract ofPharmaceutical biology · 2025Article
- A novel liposomal hydrogel loaded with deer blood peptides prevents UVB-induced skin photoaging.Scientific reports · 2025Article
- Combination of Nicotinamide andPreventive nutrition and food science · 2024Article
- Hypoglycemic and hypolipidemic effects of unsaponifiable matter from okra seed in diabetic rats.Nutrition research and practice · 2024Article
- Article
- Regulatory Mechanisms of Natural Active Ingredients and Compounds on Keratinocytes and Fibroblasts in Mitigating Skin Photoaging.Clinical, cosmetic and investigational dermatology · 2024Review
- Unsaponifiable Matter from Wheat Bran Cultivated in Korea Inhibits Hepatic Lipogenesis by Activating AMPK Pathway.Foods (Basel, Switzerland) · 2023Article
- The Role and Mechanism ofMolecules (Basel, Switzerland) · 2023Review
- Review
- Photoprotective Effects of a Hyperoside-Enriched Fraction Prepared fromPlants (Basel, Switzerland) · 2021Article
- Insight into Seasonal Change of Phytochemicals, Antioxidant, and Anti-Aging Activities of Root Bark ofMolecules (Basel, Switzerland) · 2021Article
- Ethanol Extract of Yak-Kong Fermented by Lactic Acid Bacteria from a Korean Infant Markedly Reduces Matrix Metallopreteinase-1 Expression Induced by Solar Ultraviolet Irradiation in Human Keratinocytes and a 3D Skin Model.Antioxidants (Basel, Switzerland) · 2021Article
- Comparison of Phytochemical Contents and Cytoprotective Effects of Different Rice Bran Extracts fromPreventive nutrition and food science · 2020Article
- Anti-Photoaging and Anti-Melanogenesis Effects of Fucoidan Isolated fromMarine drugs · 2020Article
- Therapeutic Effects of Cold-Pressed Perilla Oil Mainly Consisting of Linolenic acid, Oleic Acid and Linoleic Acid on UV-Induced Photoaging in NHDF Cells and SKH-1 Hairless Mice.Molecules (Basel, Switzerland) · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Unsaponifiable matter (USM) from perilla seed meal contains numerous phytochemicals, including tocopherols, phytosterols, squalene, and policosanols, that exhibit antioxidant and health-promoting properties. In this study, the protective effects of USM on UVB-induced skin aging were investigated in Hs68 cells. UVB irradiation decreased cell viability by 26% compared to the control. However, USM blocked UVB-induced cytotoxicity. Moreover, USM treatment significantly decreased the UVB-induced production of reactive oxygen species and attenuated the UVB-induced production and mRNA expression of matrix metalloproteinases (MMPs) by inhibiting the phosphorylation of mitogen-activated protein kinases and activator protein 1 (AP-1). Furthermore, UVB exposure led to a 49.4% reduction in collagen synthesis. However, USM treatment restored collagen synthesis through upregulation of the transforming growth factor beta (TGF-β)/Smad2/3 pathways. These data indicate that USM regulates the production of MMPs and collagen by modulation of the TGF-β/Smad pathway and AP-1 activity, suggesting that USM may be a useful anti-photoaging ingredient.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.