Evidence map›Paper›PMID 31847187›Full record

ArticleJournal of clinical medicine2019

Paraoxonase-1 Serum Concentration and

Mircea Vasile Milaciu, Ștefan Cristian Vesa, Ioana Corina Bocșan, Lorena Ciumărnean, Dorel Sâmpelean, Vasile Negrean, Raluca Maria Pop, Daniela Maria Matei, Sergiu Pașca, Andreea Liana Răchișan and 2 more

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 29 citations in OpenAlex.

  1. Review
  2. The Paraoxonase (International journal of molecular sciences · 2025
    Review
  3. Article
  4. A Case-Control Study Supports Genetic Contribution of theAntioxidants (Basel, Switzerland) · 2024
    Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Mitochondrial Mutations and Genetic Factors Determining NAFLD Risk.International journal of molecular sciences · 2021
    Review
  14. Statins in Non-alcoholic Steatohepatitis.Frontiers in cardiovascular medicine · 2021
    Review
  15. Review
  16. Review
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Mircea Vasile MilaciuDepartment 5-Internal Medicine, 4th Medical Clinic, Faculty of Medicine, "Iuliu Haţieganu" University of Medicine and Pharmacy, 400015 Cluj-Napoca, Romania.ORCID 0000-0002-5087-9282
Ștefan Cristian VesaDepartment 2-Functional Sciences, Discipline of Pharmacology, Toxicology and Clinical Pharmacology, Faculty of Medicine, "Iuliu Haţieganu" University of Medicine and Pharmacy, 400337 Cluj-Napoca, Romania.ORCID 0000-0003-4549-3526
Ioana Corina BocșanDepartment 2-Functional Sciences, Discipline of Pharmacology, Toxicology and Clinical Pharmacology, Faculty of Medicine, "Iuliu Haţieganu" University of Medicine and Pharmacy, 400337 Cluj-Napoca, Romania.
Lorena CiumărneanDepartment 5-Internal Medicine, 4th Medical Clinic, Faculty of Medicine, "Iuliu Haţieganu" University of Medicine and Pharmacy, 400015 Cluj-Napoca, Romania.
Dorel SâmpeleanDepartment 5-Internal Medicine, 4th Medical Clinic, Faculty of Medicine, "Iuliu Haţieganu" University of Medicine and Pharmacy, 400015 Cluj-Napoca, Romania.
Vasile NegreanDepartment 5-Internal Medicine, 4th Medical Clinic, Faculty of Medicine, "Iuliu Haţieganu" University of Medicine and Pharmacy, 400015 Cluj-Napoca, Romania.
Raluca Maria PopDepartment 2-Functional Sciences, Discipline of Pharmacology, Toxicology and Clinical Pharmacology, Faculty of Medicine, "Iuliu Haţieganu" University of Medicine and Pharmacy, 400337 Cluj-Napoca, Romania.ORCID 0000-0003-1899-5977
Daniela Maria MateiDepartment 5-Internal Medicine, 3rd Medical Clinic, Faculty of Medicine, "Iuliu Haţieganu" University of Medicine and Pharmacy, 400162 Cluj-Napoca, Romania.
Sergiu PașcaFaculty of Medicine, "Iuliu Haţieganu" University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.
Andreea Liana RăchișanDepartment of Pediatrics, "Iuliu Haţieganu" University of Medicine and Pharmacy, 400177 Cluj-Napoca, Romania.
Anca Dana BuzoianuDepartment 2-Functional Sciences, Discipline of Pharmacology, Toxicology and Clinical Pharmacology, Faculty of Medicine, "Iuliu Haţieganu" University of Medicine and Pharmacy, 400337 Cluj-Napoca, Romania.
Monica AcalovschiDoctoral School, "Iuliu Haţieganu" University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.
Iuliu Hațieganu University of Medicine and Pharmacy · RO

Funding

Iuliu Hațieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania No. 7690/72/ 15.04.2016 and 5200/62/ 01.03.2017
6 · The paper itself

Abstract

backgroundNon-alcoholic fatty liver disease (NAFLD) is an important cause of chronic liver diseases around the world. Paraoxonase-1 (PON1) is an enzyme produced by the liver with an important antioxidant role. The aim of this study was to evaluate PON1 serum concentration and MATERIALS AND

methodsWe studied a group of 81 patients with NAFLD with persistently elevated aminotransferases and a control group of 81 patients without liver diseases. We collected clinical information and performed routine blood tests. We also measured the serum concentration of PON1 and evaluated the

resultsThere was a significant difference (

conclusionsPON1 serum concentrations were diminished in patients with NAFLD, and the presence of NAFLD was linked with low PON1 concentration. The LM + MM genotypes of the

Indexed as

gene polymorphismsnon-alcoholic steatohepatitisparaoxonase-1

Identifiers

PMID31847187
PMCPMC6947206
OpenAlexW2996745874

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.