Evidence map›Paper›PMID 31847173›Full record

ArticleMolecules (Basel, Switzerland)2019

Structure-Activity Study of an All-d Antimicrobial Octapeptide D2D.

Abdullah Lone, Thomas T Thomsen, Josefine Eilsø Nielsen, Peter W Thulstrup, Rasmus N Klitgaard, Anders Løbner-Olesen, Reidar Lund, Håvard Jenssen, Paul R Hansen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Abdullah LoneDepartment of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen, Denmark.ORCID 0000-0001-7316-6640
Thomas T ThomsenDepartment of Clinical Microbiology, Rigshospitalet, Henrik Harpestrengs Vej 4A, 2100 Copenhagen, Denmark.
Josefine Eilsø NielsenDepartment of Chemistry, University of Oslo, Sem Sælands vei 26, 0371 Oslo, Norway.ORCID 0000-0001-9274-5533
Peter W ThulstrupDepartment of Chemistry, University of Copenhagen, Universitetsparken 5, 2100 Copenhagen, Denmark.ORCID 0000-0002-9241-4352
Rasmus N KlitgaardDepartment of Biology, Section for functional Genomics, University of Copenhagen, Ole Maaløes Vej 5, 2200 Copenhagen, Denmark.
Anders Løbner-OlesenDepartment of Biology, Section for functional Genomics, University of Copenhagen, Ole Maaløes Vej 5, 2200 Copenhagen, Denmark.ORCID 0000-0002-0344-6417
Reidar LundDepartment of Chemistry, University of Oslo, Sem Sælands vei 26, 0371 Oslo, Norway.
Håvard JenssenDepartment of Science and Environment, Roskilde University, 4000 Roskilde, Denmark.ORCID 0000-0003-0007-0335
Paul R HansenDepartment of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen, Denmark.ORCID 0000-0001-9357-8001

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The increasing emergence of multi-drug resistant bacteria is a serious threat to public health worldwide. Antimicrobial peptides have attracted attention as potential antibiotics since they are present in all multicellular organisms and act as a first line of defence against invading pathogens. We have previously identified a small all-d antimicrobial octapeptide amide kk(1-nal)fk(1-nal)k(nle)-NH

Indexed as

Acinetobacter baumanniiAnti-Infective AgentsBacteriaCircular DichroismDose-Response Relationship, DrugEscherichia coliHydrophobic and Hydrophilic InteractionsMicrobial Sensitivity TestsMolecular StructureOligopeptidesPseudomonas aeruginosaStaphylococcus aureusStructure-Activity RelationshipX-Ray DiffractionAnti-Infective AgentsOligopeptidesantimicrobial peptidescircular dichroismd-peptideshemolytic activityminimum inhibitory concentrationsmall angle X-ray scatteringtime-kill kinetics

Identifiers

PMID31847173
PMCPMC6943423

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.