ReviewSeminars in reproductive medicine2019
Does the KNDy Model for the Control of Gonadotropin-Releasing Hormone Pulses Apply to Monkeys and Humans?
Review in Seminars in reproductive medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 33 citations in OpenAlex.
- Non-human primates as a translational model for the study of male reproductive health.Nature reviews. Urology · 2025Review
- Effects of menopause on temperature regulation.Temperature (Austin, Tex.) · 2025Review
- Kisspeptin a potential therapeutic target in treatment of both metabolic and reproductive dysfunction.Journal of diabetes · 2024Review
- KNDy Neurons of the Hypothalamus and Their Role in GnRH Pulse Generation: an Update.Endocrinology · 2023Review
- Lesions of KNDy and Kiss1R Neurons in the Arcuate Nucleus Produce Different Effects on LH Pulse Patterns in Female Sheep.Endocrinology · 2023Article
- Disruptions in Hypothalamic-Pituitary-Gonadal Axis Development and Their IgG Modulation after Prenatal Systemic Inflammation in Male Rats.International journal of molecular sciences · 2023Article
- Neural substrates underlying rhythmic coupling of female reproductive and thermoregulatory circuits.Frontiers in physiology · 2023Review
- Targeting KNDy neurons to control GnRH pulses.Current opinion in pharmacology · 2022Review
- The role of gonadotropin-releasing hormone neurons in polycystic ovary syndrome.Journal of neuroendocrinology · 2022Review
- The mechanism underlying the pubertal increase in pulsatile GnRH release in primates.Journal of neuroendocrinology · 2022Review
- Tachykinins, new players in the control of reproduction and food intake: A comparative review in mammals and teleosts.Frontiers in endocrinology · 2022Review
- Role of KNDy Neurons Expressing Kisspeptin, Neurokinin B, and Dynorphin A as a GnRH Pulse Generator Controlling Mammalian Reproduction.Frontiers in endocrinology · 2021Review
- Adolescent Development of Biological Rhythms in Female Rats: Estradiol Dependence and Effects of Combined Contraceptives.Frontiers in physiology · 2021Article
- Genetic variants of G-protein coupled receptors associated with pubertal disorders.Reproductive medicine and biologyReview
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
There is now considerable evidence supporting the role of a subpopulation of neurons in the arcuate nucleus of the hypothalamus that coexpress kisspeptin, neurokinin B, and dynorphin (abbreviated as KNDy neurons) as the long sought-after gonadotropin-releasing hormone (GnRH) pulse generator. The "KNDy hypothesis" of pulse generation has largely been based on findings in rodents and ruminants, and there is considerably less information about the anatomical and functional organization of the KNDy subpopulation in the primate hypothalamus. In this review, we focus on the applicability of this hypothesis, and the roles of kisspeptin, neurokinin B, and dynorphin in reproduction, to humans and nonhuman primates, reviewing available data and pointing out important gaps in our current knowledge. With recent application of drugs that target KNDy peptides and their receptors to therapeutic treatments for reproductive disorders, it is imperative we fully understand the primate KNDy network and its role in the control of GnRH secretion, as well as species differences in this system that may exist between humans, nonhuman primates, and other mammals.
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Registered trials
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