Evidence map›Paper›PMID 31846864›Full record

ArticleEuropean journal of radiology2020

Radiomic features of the pancreas on CT imaging accurately differentiate functional abdominal pain, recurrent acute pancreatitis, and chronic pancreatitis.

Rouzbeh Mashayekhi, Vishwa S Parekh, Mahya Faghih, Vikesh K Singh, Michael A Jacobs, Atif Zaheer

Registry-linked trialOpen access · greenAbstract read
In one paragraph

Article in European journal of radiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06124989 (A Novel Machine Learning Model for the Prediction of Relapse of Acute Biliary Pancreatitis), which is not on this map. Cited by 28 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 2 pooled it
2.7field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06124989 unknown statusnot on this mapstarted 2024, after this paper: background citation

A Novel Machine Learning Model for the Prediction of Relapse of Acute Biliary Pancreatitis (Machine learnINg for the rElapse Risk eValuation in Acute Biliary Pancreatitis - MINERVA)

TypeobservationalSponsorUniversity of CagliariRan2024 to 2025Enrolled430ConditionsAcute Pancreatitis, Pancreatitis Due to Gallstones, Pancreatitis Biliary, Pancreatitis RelapsingArmsMINERVA Machine Learning model
3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 55 citations in OpenAlex.

  1. Artificial Intelligence in Pancreatic Imaging: A Systematic Review.United European gastroenterology journal · 2025
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Rouzbeh MashayekhiThe Russell H. Morgan Department of Radiology and Radiological Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA. Electronic address: rmashay1@jhmi.edu.
Vishwa S ParekhThe Russell H. Morgan Department of Radiology and Radiological Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA; Department of Computer Science, The Johns Hopkins University, Baltimore, MD, 21208, USA. Electronic address: vishwaparekh@jhu.edu.
Mahya FaghihPancreatitis Center, Division of Gastroenterology, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA. Electronic address: mfaghih2@jhu.edu.
Vikesh K SinghPancreatitis Center, Division of Gastroenterology, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA. Electronic address: vsingh1@jhmi.edu.
Michael A JacobsThe Russell H. Morgan Department of Radiology and Radiological Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA. Electronic address: mikej@mri.jhu.edu.
Atif ZaheerThe Russell H. Morgan Department of Radiology and Radiological Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA; Pancreatitis Center, Division of Gastroenterology, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA. Electronic address: azaheer1@jhmi.edu.
Johns Hopkins University · US

Funding

Translational Research Central ServicesP30CA006973 · NCI · JOHNS HOPKINS UNIVERSITY · PI WILLIAM George NELSON · 1985 to 2026
$208.6M
Elimination of Instrumental Bias for Quantitative Diffusion Imaging in Clinical Oncology TrialsR01CA190299 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MALYARENKO, DARIYA I. · 2015 to 2025
$6.4M
Multi-Modality Quantitiative Imaging for Evaluation of Response to Cancer TherapyU01CA140204 · NCI · JOHNS HOPKINS UNIVERSITY · PI DU, YONG, SOLNES, LILJA · 2011 to 2022
$6.1M
NCI NIH HHS P30 CA006973NCI NIH HHS R01 CA190299NCI NIH HHS U01 CA140204
6 · The paper itself

Abstract

purposePatients with recurrent abdominal pain and pancreatic enzyme elevations may be diagnosed clinically with recurrent acute pancreatitis (RAP) even with normal imaging or no imaging at all. Since neither abdominal pain nor enzyme elevations are specific for acute pancreatitis (AP), and patients with RAP often have a normal appearing pancreas on CT after resolution of an AP episode, RAP diagnosis can be challenging. This study aims to determine if quantitative radiomic features of the pancreas on CT can differentiate patients with functional abdominal pain, RAP, and chronic pancreatitis (CP).

methodContrast enhanced CT abdominal images of adult patients evaluated in a pancreatitis clinic from 2010 to 2018 with the diagnosis of RAP, functional abdominal pain, or CP were retrospectively reviewed. The pancreas was outlined by drawing region of interest (ROI) on images. 54 radiomic features were extracted from each ROI and were compared between the patient groups. A one-vs-one Isomap and Support Vector Machine (IsoSVM) classifier was also trained and tested to classify patients into one of the three diagnostic groups based on their radiomic features.

resultsAmong the study's 56 patients, 20 (35.7 %) had RAP, 19 (33.9 %) had functional abdominal pain, and 17 (30.4 %) had CP. On univariate analysis, 11 radiomic features (10 GLCM features and one NGTDM feature) were significantly different between the patient groups. The IsoSVM classifier for prediction of patient diagnosis had an overall accuracy of 82.1 %.

conclusionsCertain radiomic features on CT imaging can differentiate patients with functional abdominal pain, RAP, and CP.

Indexed as

Tomography, X-Ray ComputedAbdominal PainAdultFemaleHumansMaleMiddle AgedPancreasPancreatitisRecurrenceRetrospective StudiesTreatment OutcomeAbdomenChronic pancreatitisCTMachine learningPancreasPancreatitisRadiomicsRecurrent acute pancreatitis

Identifiers

PMID31846864
PMCPMC7968044
OpenAlexW2995087503

What OpenQuestion holds

Textmetadata
LicenceTDM
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.