ArticleCurrent biology : CB2019
No evidence for an S cone contribution to acute neuroendocrine and alerting responses to light.
Article in Current biology : CB, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
31 citing papers in PubMed, 56 citations in OpenAlex.
- Evaluation of wearable light dosimeters for circadian lighting: spectral, spatial, photometric, melanopic, and thermal performance.Npj biological timing and sleep · 2026Article
- An ipRGC-influenced/Non-Visual Spectral Occupant Model for lighting design, Part 2: Photobiological model implementation.Lighting research & technology (London, England : 2001) · 2026Article
- An ipRGC-influenced/Non-Visual Spectral Occupant Model (iNSOM) for lighting design, Part 1: Light simulation method.Lighting research & technology (London, England : 2001) · 2026Article
- Simulated natural daylight and twilight modulate activity and light sampling behaviour in mice.BMC biology · 2026Article
- Lack of strong evidence for cone photoreceptors' contribution to human melatonin suppression and alerting response to light.iScience · 2025Article
- Afternoon to early evening bright light exposure reduces later melatonin production in adolescents.Npj biological timing and sleep · 2025Article
- Toward an Indoor Lighting Solution for Social Jet Lag.Journal of biological rhythms · 2024Article
- Effects of calibrated blue-yellow changes in light on the human circadian clock.Nature human behaviour · 2024Article
- Power Analysis for Human Melatonin Suppression Experiments.Clocks & sleep · 2024Article
- Integrative Lighting Aimed at Patients with Psychiatric and Neurological Disorders.Clocks & sleep · 2023Article
- Seasonal Variation in the Responsiveness of the Melanopsin System to Evening Light: Why We Should Report Season When Collecting Data in Human Sleep and Circadian Studies.Clocks & sleep · 2023Article
- Human-Centric Lighting Research and Policy in the Melanopsin Age.Policy insights from the behavioral and brain sciences · 2023Article
- Regulation of mouse exploratory behaviour by irradiance and cone-opponent signals.BMC biology · 2023Article
- Light as a Modulator of Non-Image-Forming Brain Functions-Positive and Negative Impacts of Increasing Light Availability.Clocks & sleep · 2023Review
- Blue-light background impairs visual exogenous attention shift.Scientific reports · 2023Article
- The spectral sensitivity of human circadian phase resetting and melatonin suppression to light changes dynamically with light duration.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Electric lighting, adolescent sleep and circadian outcomes, and recommendations for improving light health.Sleep medicine reviews · 2022Review
- Spectrophotometric properties of commercially available blue blockers across multiple lighting conditions.Chronobiology international · 2022Article
- Duration invariance and intensity dependence of the human circadian system phase shifting response to brief light flashes.Proceedings. Biological sciences · 2022Article
- Recommendations for daytime, evening, and nighttime indoor light exposure to best support physiology, sleep, and wakefulness in healthy adults.PLoS biology · 2022Article
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Exposure to even moderately bright short-wavelength light in the evening can strongly suppress the production of melatonin and delay our circadian rhythm. These effects are mediated by the retinohypothalamic pathway, connecting a subset of retinal ganglion cells to the circadian pacemaker in the suprachiasmatic nucleus (SCN) in the brain. These retinal ganglion cells express the photosensitive protein melanopsin, rendering them intrinsically photosensitive (ipRGCs). But ipRGCs also receive input from the classical photoreceptors - the cones and rods. Here, in human participants, we examined whether the short-wavelength-sensitive (S) cones contribute to the neuroendocrine response to light by using stimuli which differed exclusively in the amount of S cone excitation by almost two orders of magnitude (ratio 1:83), but not in the excitation of long-wavelength-sensitive (L) and medium-wavelength-sensitive (M) cones, rods, and melanopsin. We specifically examined the S cones since the previously published action spectra for melatonin suppression [1,2] pointed to a possible role of S cones in addition to melanopsin. We find no evidence for a role of S cones in the acute alerting and melatonin-supressing response to evening light exposure.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.