Evidence map›Paper›PMID 31846606›Full record

ArticleBlood transfusion = Trasfusione del sangue2019

Prevalence, incidence and residual risk of transfusion-transmitted hepatitis B virus infection in Italy from 2009 to 2018.

Claudio Velati, Luisa Romanò, Ilaria Pati, Giuseppe Marano, Vanessa Piccinini, Liviana Catalano, Simonetta Pupella, Stefania Vaglio, Eva Veropalumbo, Francesca Masiello and 4 more

Abstract read
In one paragraph

Article in Blood transfusion = Trasfusione del sangue, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. Transfusion-transmittedThe Lancet regional health. Southeast Asia · 2025
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  7. Prevalence and Residual Risk of HIV in Volunteer Blood Donors of Zhejiang Province, China, from 2018 to 2022.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2024
    Article
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  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Uncovering occult hepatitis B in blood donations: a tale of two worlds.Blood transfusion = Trasfusione del sangue · 2019
    Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Claudio VelatiItalian Society of Transfusion Medicine and Immunohaematology, Rome, Italy.
Luisa RomanòDepartment of Biomedical Sciences for Health, University of Milan, Milan, Italy.
Ilaria PatiItalian National Blood Centre, National Institute of Health, Rome, Italy.
Giuseppe MaranoItalian National Blood Centre, National Institute of Health, Rome, Italy.
Vanessa PiccininiItalian National Blood Centre, National Institute of Health, Rome, Italy.
Liviana CatalanoItalian National Blood Centre, National Institute of Health, Rome, Italy.
Simonetta PupellaItalian National Blood Centre, National Institute of Health, Rome, Italy.
Stefania VaglioItalian National Blood Centre, National Institute of Health, Rome, Italy.
Eva VeropalumboItalian National Blood Centre, National Institute of Health, Rome, Italy.
Francesca MasielloItalian National Blood Centre, National Institute of Health, Rome, Italy.
Giulio PisaniCenter for Immunobiological Research and Evaluation, National Institute of Health, Rome, Italy.
Giuliano GrazziniItalian National Blood Centre, National Institute of Health, Rome, Italy.
Alessandro ZanettiDepartment of Biomedical Sciences for Health, University of Milan, Milan, Italy.
Giancarlo M LiumbrunoItalian National Blood Centre, National Institute of Health, Rome, Italy.
University of Milan · ITItalian Society of Physiotherapy · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn Italy, the use of nucleic acid testing for hepatitis B virus (HBV) in donor screening has allowed the detection of infections in the window phase, as well as the presence of occult infections which could potentially be transmitted. The aim of this study was to analyse the trends of epidemiological data focused on HBV infection in blood donors and to estimate the residual risk of transmitting HBV from both the window phase and occult infection over a 10-year period in Italy. MATERIALS AND

methodsData were obtained from the Italian Haemovigilance System which includes the results of screening tests for transfusion transmissible infections. During the period of this survey (2009-2018), the molecular methods used for HBV screening were transcription-mediated amplification and polymerase chain reaction tests. Prevalence and incidence were calculated. The residual risk was estimated by applying the incidence-window period model for acute cases and a more recently reported model for estimating the risk due to occult infections.

resultsA total of 17,424,535 blood donors and 30,842,794 donations were tested for HBV. Altogether, 6,250 donors tested positive for HBV markers: 4,782 (175.6×10 DISCUSSION: In Italy, the residual risk of transfusing a blood unit infected with HBV, both from window phase and occult infections, is currently very low, amounting to levels that can be considered tolerable.

Indexed as

Blood DonorsBlood SafetyHepatitis BTransfusion ReactionAdolescentAdultAgedFemaleHumansIncidenceItalyMaleMiddle AgedPolymerase Chain ReactionPrevalence

Identifiers

PMID31846606
PMCPMC6917538
OpenAlexW2995395455

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.