Evidence map›Paper›PMID 31846231›Full record

ArticleAdvanced healthcare materials2020

Engineering a Novel 3D Printed Vascularized Tissue Model for Investigating Breast Cancer Metastasis to Bone.

Haitao Cui, Timothy Esworthy, Xuan Zhou, Sung Yun Hann, Robert I Glazer, Rong Li, Lijie Grace Zhang

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced healthcare materials, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed, 1 pooled it
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 1 synthesis or guideline pooled it, 85 citations in OpenAlex.

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  16. Growing Gold Nanostars on 3D Hydrogel Surfaces.Chemistry of materials : a publication of the American Chemical Society · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Haitao CuiDepartment of Mechanical and Aerospace Engineering, The George Washington University, 3590 Science and Engineering Hall, 800 22nd Street NW, Washington, DC, 20052, USA.
Timothy EsworthyDepartment of Mechanical and Aerospace Engineering, The George Washington University, 3590 Science and Engineering Hall, 800 22nd Street NW, Washington, DC, 20052, USA.
Xuan ZhouDepartment of Mechanical and Aerospace Engineering, The George Washington University, 3590 Science and Engineering Hall, 800 22nd Street NW, Washington, DC, 20052, USA.
Sung Yun HannDepartment of Mechanical and Aerospace Engineering, The George Washington University, 3590 Science and Engineering Hall, 800 22nd Street NW, Washington, DC, 20052, USA.
Robert I GlazerDepartment of Oncology, and Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, 20007, USA.
Rong LiDepartment of Biochemistry and Molecular Medicine, The George Washington University, Washington, DC, 20052, USA.
Lijie Grace ZhangDepartment of Mechanical and Aerospace Engineering, The George Washington University, 3590 Science and Engineering Hall, 800 22nd Street NW, Washington, DC, 20052, USA.ORCID 0000-0003-3009-045X
George Washington University · USGeorgetown University · US

Funding

A Novel 3D Bioprinted Smart Vascularized Nano TissueDP2EB020549 · NIBIB · GEORGE WASHINGTON UNIVERSITY · PI ZHANG, LIJIE GRACE · 2014 to 2014
$2.3M
NIBIB NIH HHS DP2 EB020549
6 · The paper itself

Abstract

Cancer metastases are a challenge for cancer treatment due to their organ specificity and pathophysiological complexity. Engineering 3D in vitro models capable of replicating native cancer dissemination can significantly improve the understanding of cancer biology and can help to guide the development of more effective treatments. In order to better mimic the behavior of native cancer, a triculture metastatic model is created using a stereolithography printing technique with optimized inks for investigating the invasion of breast cancer (BrCa) cells into vascularized bone tissue. The printed system allows to study transendothelial migration and the colony-forming behavior of metastatic BrCa cells. The key steps of BrCa cell progression including expansion, migration, and colonization are continuously monitored and the interactions between cancer cells, vascular cells, and bone cells are systematically investigated. The study results demonstrate that the 3D printed tissue construct by incorporating multiple cells and various favorable ink matrices provides a suitable model to study the interaction between these cells in a complex vascular microenvironment. As such, the 3D printed tricultured model may serve as a valuable tool for studying metastatic breast cancer progression in bone.

Indexed as

Breast NeoplasmsBone and BonesHumansInkPrinting, Three-DimensionalTissue EngineeringTissue ScaffoldsTumor Microenvironment3D printingcancer metastasiscancer modelsoptimized inksvascularized bone

Identifiers

PMID31846231
PMCPMC7297662
OpenAlexW2994821877

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.