ReviewAdvanced healthcare materials2020
Specialty Tough Hydrogels and Their Biomedical Applications.
Review in Advanced healthcare materials, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
77 citing papers in PubMed.
- PVA Nanofibers by Solution Blow Spinning: Processing Principles, Challenges, and Biomedical Applications.Polymers · 2026Review
- Design and Application of Strong and Tough Low-Friction Hydrogels.Gels (Basel, Switzerland) · 2026Review
- Biomass-Derived Hydrogels for Load-Bearing Connective Tissue Repair: Integrative Reinforcement, Bio-Functional Design, and Emerging Pathways Toward Clinical Translation.Advanced healthcare materials · 2026Review
- Cryogel-based therapeutic platforms for disease modification in osteoarthritis.npj biomedical innovations · 2026Review
- SA/HA double-network hydrogel combined with PVDF electret membrane enhances osteogenic differentiation of DPSCs and promotes mandibular bone defect repair.Regenerative therapy · 2026Article
- A Roadmap for Extreme-Mechanics Hydrogels: From Toughening Mechanisms to Intelligent System Integration.Nano-micro letters · 2026Review
- High-performance polyimine xerogels: a lightweight and recyclable solution for high-temperature oil adsorption.RSC advances · 2026Article
- The Osteoimmunologic Basis of Biologic and Bioengineered Scaffolds in Fracture Healing.Bioengineering (Basel, Switzerland) · 2026Review
- Electrospun dressing promotes diabetic-infected wound healing via rapid and sustained antibacterial, ROS scavenging, and immune modulation ability.Journal of nanobiotechnology · 2026Article
- Transforming Fragile Hydrogel Chips Into Standardized Cartridges via Contact Line Pinning for Robust Microfluidics.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Hydrogels and Organogels for Local Anesthetic Delivery: Advances, Challenges, and Translational Perspectives.Gels (Basel, Switzerland) · 2025Review
- Mesoscale Modeling of Hydrogels Under Frictional Shear Stress.Macromolecules · 2025Article
- Engineering biomimetic zonal properties in fibre-reinforced hydrogels for functional cartilage tissue engineeringMaterials today. Bio · 2025Article
- Hydrogels from Renewable Resources: Advances in 3D Networks Based on Cellulose and Hemicellulose.Polymers · 2025Review
- Positional Fluorination of Fmoc-Phenylalanine Modulates Hydrogel Structure and Antibacterial Activity.Biomacromolecules · 2025Article
- Printable Conductive Hydrogels and Elastomers for Biomedical Application.Gels (Basel, Switzerland) · 2025Review
- Integrating Deep Learning and Real-Time Imaging to Visualize In Situ Self-Assembly of Self-Healing Interpenetrating Polymer Networks Formed by Protein and Polysaccharide Fibers.ACS applied materials & interfaces · 2025Article
- Phase-Conversion Stiffened Dual-Network Hydrogel for Fracture Plugging in Oil-Based Drilling Fluid.Gels (Basel, Switzerland) · 2025Article
- Engineering principles of zwitterionic hydrogels: Molecular architecture to manufacturing innovations for advanced healthcare materials.Materials today. Bio · 2025Review
- Fabrication and Characterization of Tetra-PEG-Derived Hydrogels of Controlled Softness.Macromolecules · 2025Article
17 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Hydrogels have long been explored as attractive materials for biomedical applications given their outstanding biocompatibility, high water content, and versatile fabrication platforms into materials with different physiochemical properties and geometries. Nonetheless, conventional hydrogels suffer from weak mechanical properties, restricting their use in persistent load-bearing applications often required of materials used in medical settings. Thus, the fabrication of mechanically robust hydrogels that can prolong the lifetime of clinically suitable materials under uncompromising in vivo conditions is of great interest. This review focuses on design considerations and strategies to construct such tough hydrogels. Several promising advances in the proposed use of specialty tough hydrogels for soft actuators, drug delivery vehicles, adhesives, coatings, and in tissue engineering settings are highlighted. While challenges remain before these specialty tough hydrogels will be deemed translationally acceptable for clinical applications, promising preliminary results undoubtedly spur great hope in the potential impact this embryonic research field can have on the biomedical community.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.