ArticleBrain and behavior2020
Predicting hemorrhagic transformation and its timing from maximum cerebral lesion diameter in nonlacunar ischemic strokes.
Article in Brain and behavior, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Inferior vena cava hyperechoic structure in a patient with cardiac myxoma: a surgical case report and literature review.General thoracic and cardiovascular surgery cases · 2026Article
- Prognostic Value of the Cholesterol, High-Density Lipoprotein, and Glucose Index and Remnant Cholesterol Inflammatory Index in Young Patients with Acute Ischemic Stroke.Journal of clinical medicine · 2026Article
- Volumetric Infarct Size Predicts Secondary Haemorrhagic Transformation of Ischaemic Stroke.Cerebrovascular diseases (Basel, Switzerland) · 2026Article
- The lacunar infarction with persistent trigeminal artery and delayed symptomatic hemorrhagic transformation: a case report.BMC neurology · 2025Article
- A Case of Development and Rapid Increase in the Microbleeds after Pipeline Placement for an Intracranial Unruptured Aneurysm.NMC case report journal · 2025Article
- Cerebrolysin, hemorrhagic transformation, and anticoagulation timing after reperfusion therapy in stroke:Frontiers in pharmacology · 2025Article
- Constructing machine learning models based on non-contrast CT radiomics to predict hemorrhagic transformation after stoke: a two-center study.Frontiers in neurology · 2024Article
- Early Hemorrhagic Transformation after Reperfusion Therapy in Patients with Acute Ischemic Stroke: Analysis of Risk Factors and Predictors.Brain sciences · 2023Article
- Contemporary Antiplatelet and Anticoagulant Therapies for Secondary Stroke Prevention: A Narrative Review of Current Literature and Guidelines.Current neurology and neuroscience reports · 2023Review
- Successful use of therapeutic anticoagulation therapy in two patients with moderate stroke from the second day of onset: A case report and literature review.Annals of medicine and surgery (2012) · 2022Article
- Prognostic significance of diabetes and stress hyperglycemia in acute stroke patients.Diabetology & metabolic syndrome · 2022Article
- Radiomics-based infarct features on CT predict hemorrhagic transformation in patients with acute ischemic stroke.Frontiers in neuroscience · 2022Article
- Extent of white matter lesion is associated with early hemorrhagic transformation in acute ischemic stroke related to atrial fibrillation.Brain and behavior · 2021Article
- A Review of Risk Factors and Predictors for Hemorrhagic Transformation in Patients with Acute Ischemic Stroke.International journal of vascular medicine · 2021Review
- Venous thromboembolism prevention with low molecular weight heparin may reduce hemorrhagic transformation in acute ischemic stroke.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2020Article
- Predicting hemorrhagic transformation and its timing from maximum cerebral lesion diameter in nonlacunar ischemic strokes.Brain and behavior · 2020Article
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9 authors.
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Abstract
objectivesWe performed this retrospective cohort study to establish which factors are mostly indicative of the appearance of hemorrhagic transformation (HT) and of its time course in a sample of nonlacunar ischemic strokes. MATERIALS AND
methodsIn 402 patients with nonlacunar ischemic stroke (75.0 ± 12.7 years, 192 male), clinical, laboratory, and neuroimaging variables obtained during the first 3 days of hospitalization were compared between patients with and without HT at computer tomography scan.
resultsHT was documented in 129 patients (32.1%), including 36 with parenchymal hematoma (PH), after a median time of 6 days (range 1-27). Many variables were univariately associated with HT, but only 5 of them were confirmed in Cox regression (Hazard Ratio, 95% Confidence Interval): maximum cerebral lesion diameter (CLD) in cm (1.12, 1.06-1.18; p = .0001), hemoglobin in g/dl (1.16, 1.06-1.27; p = .002), blood glucose in mmol/L (1.10, 1.03-1.18; p = .007), prior anticoagulant therapy (1.82, 1.10-3.03; p = .02), and edema with mass effect (1.72, 1.08-2.75; p = .02). Thus, the most significant predictor was CLD. The overall risk of HT was minimum for CLD < 2 cm (1.5%), intermediate for CLD ≥ 2 and < 5 cm (22%), and maximum for CLD ≥ 5 cm (58%). The residual probability of having HT decreased progressively over time, and a simple formula is proposed to predict, from CLD in cm, when the probability of HT falls below 10%.
conclusionsThe main determinant of HT was CLD, a simple quantitative parameter that could prove useful, in particular, in deciding the timing of anticoagulation in cardioembolic stroke patients.
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