ArticleJournal of clinical laboratory analysis2020
Widespread of non-typeable Haemophilus influenzae with high genetic diversity after two decades use of Hib vaccine in China.
Article in Journal of clinical laboratory analysis, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 17 citations in OpenAlex.
- Encapsulation of Protein-Based Drug Carriers for Controlled Loading and Releasing Efficiency: A Review.The protein journal · 2026Review
- Multidrug resistance and genomic characteristics of nontypeableMicrobiology spectrum · 2026Article
- Molecular and Drug Resistance Characteristics ofMicroorganisms · 2025Article
- Comparison of the adherence of nontypeable haemophilus influenzae to lung epithelial cells.BMC infectious diseases · 2024Article
- Characterization of Serotypes and Molecular Drug Resistance Patterns ofPolish journal of microbiology · 2023Article
- Molecular Epidemiology and Antibiotic Resistance Analysis of Non-TypeableAntibiotics (Basel, Switzerland) · 2023Article
- Can non-typeablePediatric investigation · 2023Article
- Epidemic Trends and Biofilm Formation Mechanisms of Haemophilus influenzae: Insights into Clinical Implications and Prevention Strategies.Infection and drug resistance · 2023Review
- Real-time multiple cross displacement amplification assay for rapid and sensitive detection of Haemophilus influenzae.Frontiers in cellular and infection microbiology · 2022Article
- Molecular epidemiology and antimicrobial resistance ofFrontiers in public health · 2022Article
- NontypeableJournal of immunology (Baltimore, Md. : 1950) · 2021Article
- Particulate air pollution and respiratory Haemophilus influenzae infection in Mianyang, southwest China.Environmental science and pollution research international · 2021Article
- Invasive non-typeable Haemophilus influenzae infection due to endometritis associated with adenomyosis.BMC infectious diseases · 2020Article
- Widespread of non-typeable Haemophilus influenzae with high genetic diversity after two decades use of Hib vaccine in China.Journal of clinical laboratory analysis · 2020Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThe aim of this study was to analyze the microbiological characteristics of nasopharyngeal carriage Haemophilus influenzae isolates collected from children with respiratory infections in Beijing hospital and Youyang Hospital of China.
methodsThe serotypes of all isolates were determined using latex agglutinated antisera (a-f). The minimum inhibitory concentrations (MICs) of 11 antibiotics were determined using E-test strips. For the beta-lactamase-negative ampicillin-resistant (BLNAR) isolates, ftsI gene was sequenced based on fragments amplified by PCR. STs of H influenzae isolates were determined by multi-locus sequence typing.
resultsThe overall carriage rate of H influenzae in the study population was 9.1% (362/3984). One hundred and ninety H influenzae isolates which were selected in our study were non-typeable (NTHi) and 44 (23.2%) of them were positive for β-lactamase. All isolates were susceptible to ceftriaxone and levofloxacin. Susceptibility rates to erythromycin and sulfamethoxazole-trimethoprim in Beijing were significantly higher than Youyang (P < .05). Thirty-six BLNAR isolates were identified. The MLST analysis showed 108 STs in 190 isolates, the most common of which were ST408 (11, 5.8%), ST914 (10, 5.3%), ST57 (9, 4.7%), and ST834 (6, 3.2%). Twelve STs were detected in both of the study sites, which covered 63 isolates.
conclusionsAll isolates in the present study were NTHi, which suggested widespread of this type in China. The BLNAR isolates were detected more frequently than before. Because high genetic diversity of NTHi isolates of H influenzae exists worldwide, it is important to continuously monitor these bacteria in the future.
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