ArticleCancer2020
New-onset persistent opioid use following breast cancer treatment in older adult women.
Article in Cancer, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- A systematic review of assessment approaches to predict opioid misuse in people with cancer.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022Pooled it
- Changes in opioid prescribing and high-risk co-prescribing after implementation of the 2016 CDC opioid guideline among older adults with and without cancer.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Article
- Persistent Postmastectomy Pain: A Comparison of Diagnosis and Patient-reported Outcome Measures in 6988 Patients.Plastic and reconstructive surgery. Global open · 2026Article
- Article
- Opioid prescribing trends and pain scores among adult patients with cancer in a large health system.Cancer · 2025Article
- Observational
- Hydrocodone Rescheduling and Opioid Prescribing Disparities in Breast Cancer Patients.Cancers · 2025Article
- Persistent prescription opioid use and all-cause mortality following the first-year breast cancer survivorship.JNCI cancer spectrum · 2025Article
- Associations Among Self-Advocacy, Patient-Centered Communication, Pain Intensity, and Opioid Stigma in Older Adult Female Breast Cancer Survivors.Oncology nursing forum · 2025Article
- Persistent opioid use is associated with a shorter myeloma survival.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Article
- Opioid use and adverse health effects in breast cancer survivors.The oncologist · 2025Article
- Article
- Long-term Health Outcomes of New Persistent Opioid Use After Gastrointestinal Cancer Surgery.Annals of surgical oncology · 2024Article
- Trends in new and persistent opioid use in older adults with and without cancer.Journal of the National Cancer Institute · 2024Article
- The importance of translationally evaluating steroid hormone contributions to substance use.Frontiers in neuroendocrinology · 2023Review
- Pain management practices for outpatients with breast cancer.Exploratory research in clinical and social pharmacy · 2022Article
- Patterns and Trends in Receipt of Opioids Among Patients Receiving Treatment for Cancer in a Large Health System.Journal of the National Comprehensive Cancer Network : JNCCN · 2022Article
- Predictors of Chronic Opioid Use: A Population-Level Analysis of North Carolina Cancer Survivors Using Multi-Payer Claims.Journal of the National Cancer Institute · 2021Article
- Opioid Use Disorder and Overdose in Older Adults With Breast, Colorectal, or Prostate Cancer.Journal of the National Cancer Institute · 2021Article
- Trends and patterns in the use of opioids among metastatic breast cancer patients.Scientific reports · 2020Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundPatients with cancer-related pain are underrepresented in the opioid literature despite high opioid exposure and numerous risk factors for adverse opioid outcomes, including unnecessary persistent opioid use. The objective of this study was to determine the extent, historical trends, and predictors of new-onset persistent opioid use among older adult women after active breast cancer treatment.
methodsUsing Surveillance, Epidemiology, and End Results-Medicare data for opioid-naive women diagnosed with stage 0 to III breast cancer at the age of 66 to 90 years between 2008 and 2013, this study estimated overall and quarterly adjusted probabilities of new-onset persistent opioid use, which was defined as receiving ≥90 days' supply of opioids in the year after active breast cancer treatment. Sensitivity analyses were conducted with an alternative definition of persistent opioid use: any opioid fill 90 to 180 days after active cancer treatment.
resultsNearly two-thirds of the subjects received prescription opioid therapy during cancer treatment. Quarterly probabilities of new-onset persistent opioid use after active treatment ranged from 2% to 4%; in sensitivity analyses, the alternative outcome definition resulted in predicted probabilities ranging from 11.4% to 14.7%. Subjects with more advanced disease, a higher comorbidity burden, a low-income status, and greater opioid exposure during active cancer treatment were more likely to develop persistent opioid use.
conclusionsPersistent opioid use was an infrequent occurrence among older adult patients with breast cancer completing cancer treatment between 2008 and 2013. This finding was encouraging because of the concerning opioid trends seen in noncancer populations. However, opportunities to further mitigate unsafe opioid use as a complication of cancer care, including standardization of persistent opioid use definitions, should be explored.
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