ArticleJournal of the National Cancer Institute2020
Emergency Department Visits for Opioid Overdoses Among Patients With Cancer.
Article in Journal of the National Cancer Institute, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 46 citations in OpenAlex.
- Opioid prescribing trends and pain scores among adult patients with cancer in a large health system.Cancer · 2025Article
- Comparative Effectiveness of Opioids and Opioid Substitutes on Pain and Health Related Quality of Life Among Cancer Survivors.Cancer medicine · 2025Article
- Persistent opioid use is associated with a shorter myeloma survival.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Article
- Emerging advances in drug delivery systems (DDSs) for optimizing cancer complications.Materials today. Bio · 2025Review
- Clinician Ordering and Management Patterns of Urine Toxicology Results at a Cancer Center.Journal of pain and symptom management · 2024Article
- Opioid tapering in older cancer survivors does not increase psychiatric or drug hospitalization rates.Journal of the National Cancer Institute · 2024Article
- A secondary analysis: the impact of pre-existing chronic pain among patients with cancer presenting to the emergency department with acute pain.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024Article
- Article
- Long-term opioid therapy trajectories and overdose in patients with and without cancer.BMJ oncology · 2023Article
- Psychological Evaluation of Patients With Cancer Presenting to the Emergency Department With Pain: Independent Predictors of Worse Pain Severity, Interference, and Higher Hourly Opioid Administration.JCO oncology practice · 2022Article
- Impacts of an Opioid Safety Initiative on US Veterans Undergoing Cancer Treatment.Journal of the National Cancer Institute · 2022Article
- Prevalence of Opioid Use Disorder among Patients with Cancer-Related Pain: A Systematic Review.Journal of clinical medicine · 2022Review
- Risk of an Opioid-Related Emergency Department Visit or Hospitalization Among Older Breast, Colorectal, Lung, and Prostate Cancer Survivors.Mayo Clinic proceedings · 2022Article
- Article
- New and persistent controlled substance use among patients undergoing mastectomy and reconstructive surgery.Breast cancer research and treatment · 2021Article
- Assessing opioid overdose risk: a review of clinical prediction models utilizing patient-level data.Translational research : the journal of laboratory and clinical medicine · 2021Review
- Racial, Ethnic, and Socioeconomic Discrepancies in Opioid Prescriptions Among Older Patients With Cancer.JCO oncology practice · 2021Observational
- Opioid Use Disorder and Overdose in Older Adults With Breast, Colorectal, or Prostate Cancer.Journal of the National Cancer Institute · 2021Article
- Evaluation of emergency departments visits in patients treated with immune checkpoint inhibitors.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021Article
- Reduced Opioid Prescribing by Oncologists: Progress Made, or Ground Lost?Journal of the National Cancer Institute · 2021Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundPatients with cancer may be at risk of high opioid use due to physical and psychosocial factors, although little data exist to inform providers and policymakers. Our aim is to examine overdoses from opioids leading to emergency department (ED) visits among patients with cancer in the United States.
methodsThe Healthcare Cost and Utilization Project Nationwide Emergency Department Sample was queried for all adult cancer-related patient visits with a primary diagnosis of opioid overdose between 2006 and 2015. Temporal trends and baseline differences between patients with and without opioid-related ED visits were evaluated. Multivariable logistic regression analysis was used to identify risk factors associated with opioid overdose. All statistical tests were two-sided.
resultsBetween 2006 and 2015, there were a weighted total of 35 339 opioid-related ED visits among patients with cancer. During this time frame, the incidence of opioid-related ED visits for overdose increased twofold (P < .001). On multivariable regression (P < .001), comorbid diagnoses of chronic pain (odds ratio [OR] 4.51, 95% confidence interval [CI] = 4.13 to 4.93), substance use disorder (OR = 3.54, 95% CI = 3.28 to 3.82), and mood disorder (OR = 3.40, 95% CI = 3.16 to 3.65) were strongly associated with an opioid-related visit. Patients with head and neck cancer (OR = 2.04, 95% CI = 1.82 to 2.28) and multiple myeloma (OR = 1.73, 95% CI = 1.32 to 2.26) were also at risk for overdose.
conclusionsOver the study period, the incidence of opioid-related ED visits in patients with cancer increased approximately twofold. Comorbid diagnoses and primary disease site may predict risk for opioid overdose.
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