ArticleeLife2019
Single-cell modeling of routine clinical blood tests reveals transient dynamics of human response to blood loss.
Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Differences Between Glycemia Estimates from Hemoglobin A1c and Continuous Glucose Monitoring and Their Association with Complete Blood Counts.Diabetes technology & therapeutics · 2026Article
- Inflammatory Markers Stratify Surgical Outcomes in Pediatric Airway Reconstruction.The Laryngoscope · 2026Article
- A minimal mathematical model of red blood cell homeostasis in anemia.PLoS computational biology · 2026Article
- Development and validation of a predictive model for hospital mortality in patients with community-acquired pneumonia admitted to the intensive care unit.The Journal of international medical research · 2025Article
- Transformer-based artificial intelligence on single-cell clinical data for homeostatic mechanism inference and rational biomarker discovery.medRxiv : the preprint server for health sciences · 2025Article
- The Red Cell Distribution Width-to-Albumin Ratio Predicts 1-Year Mortality in Patients with Chronic Obstructive Pulmonary Disease: Evidence From MIMIC-IV and NHANES.International journal of chronic obstructive pulmonary disease · 2025Article
- Effects of an antimicrobial peptide on transport- and novel environment-induced stress in British Shorthair cats.Frontiers in veterinary science · 2025Article
- Red Blood Cell Distribution Width Is Not a Predictor of Hospital Mortality in Elderly and Nonelderly COVID-19-Infected Patients: A Prospective Study at a Brazilian Quaternary University Hospital.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2025Article
- Red blood cell distribution width is associated with increased interactions of blood cells with vascular wall.Scientific reports · 2022Article
- Multivariable analysis of clinical and laboratory data manifestations predicting severity and mortality risk in patients with Coronavirus disease 2019 in the mountainous west of Iran: a retrospective single-center study.Asian biomedicine : research, reviews and news · 2022Article
- Evaluating red blood cell distribution width from community blood tests as a predictor of hospitalization and mortality in adults with SARS-CoV-2: a cohort study.Annals of medicine · 2021Article
- Genetic therapies for the first molecular disease.The Journal of clinical investigation · 2021Review
- Association of Red Blood Cell Distribution Width With Mortality Risk in Hospitalized Adults With SARS-CoV-2 Infection.JAMA network open · 2020Article
- Increased Red Cell Distribution Width Is Associated With Disease Severity in Hospitalized Adults With SARS-CoV-2 Infection: An Observational Multicentric Study.Frontiers in medicine · 2020Article
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Authors and funding
4 authors.
Funding
Abstract
Low blood count is a fundamental disease state and is often an early sign of illnesses including infection, cancer, and malnutrition, but our understanding of the homeostatic response to blood loss is limited, in part by coarse interpretation of blood measurements. Many common clinical blood tests actually include thousands of single-cell measurements. We present an approach for modeling the unsteady-state population dynamics of the human response to controlled blood loss using these clinical measurements of single-red blood cell (RBC) volume and hemoglobin. We find that the response entails (1) increased production of new RBCs earlier than is currently detectable clinically and (2) a previously unrecognized decreased RBC turnover. Both component responses offset the loss of blood. The model provides a personalized dimensionless ratio that quantifies the balance between increased production and delayed clearance for each individual and may enable earlier detection of both blood loss and the response it elicits.
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Registered trials
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