SynthesisCartilage2021
Cartilage Restoration of Patellofemoral Lesions: A Systematic Review.
Synthesis in Cartilage, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 45 citations in OpenAlex.
- [Guideline for the treatment of patellofemoral cartilage defects/arthrosis].Orthopadie (Heidelberg, Germany) · 2025Guideline
- Magnetic resonance imaging is able to detect patellofemoral focal cartilage injuries: a systematic review with meta-analysis.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2023Pooled it
- Outcomes of Restorative Treatment for Isolated Patellar Cartilage Lesions: A Systematic Review and Meta-analysis.Orthopaedic journal of sports medicine · 2026Review
- Cartilage restoration procedures in patellofemoral stabilization.Annals of joint · 2026Review
- A comprehensive review of curcumin-based scaffolds in cartilage tissue engineering.Stem cell research & therapy · 2025Review
- [Patellar cartilage repair-current concepts and evidence].Orthopadie (Heidelberg, Germany) · 2025Review
- AMIC achieves sustained clinical improvement in isolated patellar cartilage defects over 5 years, correlating with MRI.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2025Article
- Joint preservation procedures: osteotomies about the knee.Annals of joint · 2025Review
- Charting a quarter-century of commercial cartilage regeneration products.Journal of orthopaedic translation · 2025Review
- Preliminary evaluation of full volume strain measurement in patellar cartilage following osteochondral allograft transplantation using magnetic resonance imaging.Frontiers in bioengineering and biotechnology · 2025Article
- Treatment of Patellar Chondral Lesions With Concomitant Matrix-Induced Autologous Chondrocyte Implantation, Medial Patellofemoral Ligament Reconstruction, and Tibial Tubercle Osteotomy.Arthroscopy techniques · 2024Article
- Cartilage Integrity: A Review of Mechanical and Frictional Properties and Repair Approaches in Osteoarthritis.Healthcare (Basel, Switzerland) · 2024Review
- Clinical and Radiological Outcomes at ≥10-Year Follow-up After Matrix-induced Autologous Chondrocyte Implantation in the Patellofemoral Joint.The American journal of sports medicine · 2024Article
- Impact of Wiberg Patellar Type on Outcomes and Survival Following Cell-Based Cartilage Repair for Patellar Chondral Lesions at Midterm Follow-up.The American journal of sports medicine · 2024Article
- All-Arthroscopic Matrix-Associated Autologous Chondrocyte Implantation for a Trochlear Defect.Arthroscopy techniques · 2024Article
- Article
- Fixation of an Osteochondral Lesion of the Femoral Intercondylar Groove Using Autogenous Osteochondral Grafts and Bioabsorbable Pins in a Patient with Open Physes: A Case Report.Medicina (Kaunas, Lithuania) · 2022Article
- Case Report: Three-dimensional printed prosthesis reconstruction for patello-femoral large osteochondral defects in a patient with distal femoral giant cell tumour: A case report.Frontiers in bioengineering and biotechnology · 2022Article
- Osteochondral Allograft Transplant of the Patella Using Femoral Condylar Allografts: Magnetic Resonance Imaging and Clinical Outcomes at Minimum 2-Year Follow-up.Orthopaedic journal of sports medicine · 2020Article
- Tibial Tubercle Osteotomy With Matrix-Associated Autologous Chondrocyte Implantation and Lateral Retinacular Lengthening for a Patellar Chondral Defect.Video journal of sports medicineArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 8 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThis study aimed to systematically analyze the postoperative clinical, functional, and imaging outcomes, complications, reoperations, and failures following patellofemoral cartilage restoration surgery.
methodsThis review was conducted according to the guidelines of Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). PubMed, EMBASE, and Cochrane Library databases were searched up to August 31, 2018, to identify clinical studies that assessed surgical outcomes of patellofemoral cartilage restoration surgery. The Methodological Index for Non-Randomized Studies (MINORS) was used to assess study quality.
resultsForty-two studies were included comprising 1,311 knees (mean age of 33.7 years and 56% males) and 1,309 patellofemoral defects (891 patella, 254 trochlear, 95 bipolar, and 69 multiple defects, including the patella or trochlea) at a mean follow-up of 59.2 months. Restoration techniques included autologous chondrocyte implantation (56%), particulated juvenile allograft cartilage (12%), autologous matrix-induced chondrogenesis (9%), osteochondral autologous transplantation (9%), and osteochondral allograft transplantation (7%). Significant improvement in at least one score was present in almost all studies and these surpassed the minimal clinically important difference threshold. There was a weighted 19%, 35%, and 6% rate of reported complications, reoperations, and failures, respectively. Concomitant patellofemoral surgery (51% of patients) mostly did not lead to statistically different postoperative outcomes.
conclusionNumerous patellofemoral restoration techniques result in significant functional improvement with a low rate of failure. No definitive conclusions could be made to determine the best surgical technique since comparative studies on this topic are rare, and treatment choice should be made according to specific patient and defect characteristics. LEVEL OF EVIDENCE: Level IV, systematic review of level II to IV studies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.