Evidence map›Paper›PMID 31845549›Full record

ArticleNeuropsychopharmacology reports2020

OX

Masami Yamaguchi, Manabu Ishikawa, Yuri Aono, Tadashi Saigusa

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuropsychopharmacology reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. OXNeuropsychopharmacology reports · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Masami YamaguchiDepartment of Anesthesiology, Nihon University School of Dentistry at Matsudo, Matsudo, Japan.
Manabu IshikawaDepartment of Anesthesiology, Nihon University School of Dentistry at Matsudo, Matsudo, Japan.
Yuri AonoDepartment of Pharmacology, Nihon University School of Dentistry at Matsudo, Matsudo, Japan.
Tadashi SaigusaDepartment of Pharmacology, Nihon University School of Dentistry at Matsudo, Matsudo, Japan.ORCID 0000-0001-6325-9616
Nihon University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsOrexin-A is known to induce anti-nociceptive effects in animal models of chronic pain. We have found that orexin-A inhibits KCl loading-induced increases in the intracellular calcium ion levels ([Ca

methodsPaw withdrawal and threshold force in response to tactile stimuli were evaluated using von Frey filaments. Sham-operated rats served as controls. [Ca

resultsSeven days after sciatic nerve ligation, paw withdrawal and threshold force for tactile stimuli were increased and reduced, respectively. KCl loading to neurons from either sciatic nerve-ligated or control rats increased relative fluorescence intensity. The KCl-induced increase in relative fluorescence intensity in sciatic nerve-ligated, but not that of control, rats was inhibited by orexin-A. The OX

conclusionThe present findings constitute neuropharmacological evidence that OX

Indexed as

AnimalsBehavior, AnimalCalciumChronic PainDisease Models, AnimalGanglia, SpinalHyperalgesiaMaleMitochondrial ProteinsNerve Fibers, UnmyelinatedNeuralgiaOrexin Receptor AntagonistsOrexin ReceptorsPotassium ChlorideRatsRats, WistarCalciumHcrtr2 protein, ratMitochondrial ProteinsOrexin Receptor AntagonistsOrexin ReceptorsOxr1 protein, ratPotassium Chloridechronic painintracellular calcium ion levelsorexin-Aorexin receptorrat

Identifiers

PMID31845549
PMCPMC7292216
OpenAlexW2996347227

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.