ArticleAddiction (Abingdon, England)2020
Family structure and alcohol use disorder: a register-based cohort study among offspring with and without parental alcohol use disorder.
Article in Addiction (Abingdon, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 25 citations in OpenAlex.
- Genetic Architecture of Alcohol Use Disorder in Nepal.medRxiv : the preprint server for health sciences · 2025Article
- Using ecological momentary data to inform a web-based intervention for romantic partners concerned about their loved ones' drinking: Study protocol.Contemporary clinical trials communications · 2025Article
- Prevalence and Factors Associated With Alcohol Use Disorder Among People Attending Primary Health Care Facilities in Rupandehi District, Nepal.Global health, epidemiology and genomics · 2025Article
- Adverse health outcomes in offspring of parents with alcohol-related liver disease: Nationwide Danish cohort study.PLoS medicine · 2024Article
- Beyond the Laws: Parental Monitoring, Perceived Acceptability of Underage Drinking and Alcohol Use Among Belgian Youth.Journal of youth and adolescence · 2024Article
- Parent-child separation and intergenerational transmission of substance use and disorder: Testing across three generations.Development and psychopathology · 2024Article
- Sleep Characteristics Among Children with a Parental History of Alcohol Use Disorder.Current addiction reports · 2024Review
- Parental Divorce and Trajectories of Alcohol Consumption in Men: A Genetically Informative Perspective.Journal of studies on alcohol and drugs · 2023Article
- Problematic parental substance use, childhood family structures and adverse outcomes in young adulthood.Nordisk alkohol- & narkotikatidskrift : NAT · 2023Article
- Social support and risk of mortality in cirrhosis: A cohort study.JHEP reports : innovation in hepatology · 2023Article
- Mortality in adult children of parents with alcohol use disorder: a nationwide register study.European journal of epidemiology · 2022Article
- Patients With Alcohol Use Disorders and Their Concerned Others: Concordance of Lived Experience as a Moderator of Treatment Outcomes.Journal of studies on alcohol and drugs · 2021Article
- Commentary on Holst et al. (2020): Genetically informative research can clarify mechanisms linking non-intact family structure and alcohol use disorder.Addiction (Abingdon, England) · 2020Article
- Alcohol-related mortality following the loss of a child: a register-based follow-up study from Norway.BMJ open · 2020Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsTo assess whether parental alcohol use disorder (AUD) is associated with higher risks of living in a non-intact family and assess whether non-intact family structure is associated with higher risks of AUD in the offspring.
designProspective cohort study.
settingDanish nation-wide registries.
participantsA total of 9948 parental AUD offspring and 98 136 reference offspring from the Danish population. MEASUREMENTS: Family structure assessed at birth and at each birthday until age 15 as intact or non-intact (with mother only, father only or neither parent); years lived in an intact family defined as total number of years lived with both parents from birth until the 15th birthday; AUD defined as registration in medical, treatment and cause of death registries. Data were analyzed by Cox regression.
findingsAt birth, 30.9% [95% confidence interval (CI) = 29.1-32.6] of parental AUD offspring and 10.7% (95% CI = 10.3-11.0) of reference offspring lived in a non-intact family. At age 15, the numbers were 84.6% (95% CI = 83.9-85.3) and 38.4% (95% CI = 38.1-38.7). Parental AUD was associated with a higher risk of offspring AUD [hazard ratio (HR) = 1.88, 95% CI = 1.74-2.02]. Offspring were at lower risk of AUD if they lived 15 years in an intact family compared with offspring who never lived in an intact family (HR = 0.67, 95% CI = 0.52-0.87 for those with parental AUD, and HR = 0.53, 95% CI = 0.48-0.59 for those whose parents did not have AUD). Findings were inconclusive as to whether or not an association was present between family structure and AUD among offspring with parental AUD and reference offspring.
conclusionsThe prevalence of non-intact family structure appears to be higher in offspring of parents with alcohol use disorder (AUD) than among offspring from the general population. Parental AUD appears to be associated with increased risk of offspring AUD, and non-intact family structure appears to be associated with increased risk of offspring AUD regardless of parental AUD.
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