Evidence map›Paper›PMID 31845337›Full record

ArticleJournal of inherited metabolic disease2020

The 1-

Mendy M Welsink-Karssies, Dewi van Harskamp, Sacha Ferdinandusse, Carla E M Hollak, Hidde H Huidekoper, Mirian C H Janssen, E Marleen Kemper, Janneke G Langendonk, M Estela Rubio-Gozalbo, Maaike C de Vries and 3 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of inherited metabolic disease, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. The 1-Journal of inherited metabolic disease · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 1 country.

Mendy M Welsink-KarssiesDepartment of Pediatrics, Division of Metabolic Disorders, Emma Children's Hospital, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.ORCID 0000-0003-4803-1618
Dewi van HarskampDepartment of Pediatrics, Stable Isotope Laboratory, Emma Children's Hospital, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Sacha FerdinandusseLaboratory Genetic Metabolic Diseases, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Carla E M HollakDepartment of Internal Medicine, Division of Endocrinology and Metabolism, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Hidde H HuidekoperDepartment of Pediatrics, Center for Lysosomal and Metabolic Diseases, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Mirian C H JanssenDepartment of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.
E Marleen KemperDepartment of Pharmacy, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Janneke G LangendonkDepartment of Internal Medicine, Center for Lysosomal and Metabolic Diseases, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, The Netherlands.
M Estela Rubio-GozalboDepartment of Pediatrics and Department of Clinical Genetics, Maastricht University Medical Center, Maastricht, The Netherlands.
Maaike C de VriesDepartment of Pediatrics, Radboud University Medical Center, Nijmegen, The Netherlands.
Frits A WijburgDepartment of Pediatrics, Division of Metabolic Disorders, Emma Children's Hospital, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Henk SchierbeekDepartment of Pediatrics, Stable Isotope Laboratory, Emma Children's Hospital, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Annet M BoschDepartment of Pediatrics, Division of Metabolic Disorders, Emma Children's Hospital, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Emma Kinderziekenhuis · NLAmsterdam Neuroscience · NLErasmus MC · NLRadboud University Nijmegen · NLAmsterdam University Medical Centers · NLMaastricht University Medical Centre · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Classical galactosemia (CG) patients frequently develop long-term complications despite early dietary treatment. The highly variable clinical outcome is poorly understood and a lack of prognostic biomarkers hampers individual prognostication and treatment. The aim of this study was to investigate the association between residual galactose oxidation capacity and clinical and biochemical outcomes in CG patients with varying geno- and phenotypes. The noninvasive 1-

Indexed as

AdolescentAdultBreath TestsCase-Control StudiesChildChild, PreschoolFemaleGalactoseGalactosemiasGalactosephosphatesGenotypeHomozygoteHumansMaleMiddle AgedOxidation-ReductionGalactoseGalactosephosphatesUTP-Hexose-1-Phosphate Uridylyltransferase13CO2galactose oxidationinborn error of metabolismisotope ratio mass spectrometry

Identifiers

PMID31845337
PMCPMC7317391
OpenAlexW2995912833

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.