Evidence map›Paper›PMID 31845296›Full record

ArticleBrazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]2020

Time-kill curves of daptomycin and Monte Carlo simulation for the treatment of bacteraemia caused by Enterococcus faecium.

Bruna Kochhann Menezes, Izabel Almeida Alves, Keli Jaqueline Staudt, Betina Montanari Beltrame, Letícia Venz, Lessandra Michelin, Bibiana Verlindo Araujo, Leandro Tasso

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PubMed Full text at PMC Publisher
In one paragraph

Article in Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology], 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Stability of Daptomycin in Dextrose and Icodextrin-Based Peritoneal Dialysis Solutions.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Bruna Kochhann MenezesHealth Sciences Graduate Program, University of Caxias do Sul, Caxias do Sul, Brazil.
Izabel Almeida AlvesPharmaceutical Sciences Graduate Program, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
Keli Jaqueline StaudtMedical Sciences Graduate Program, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
Betina Montanari BeltrameCollege of Pharmacy, University of Caxias do Sul, Caxias do Sul, Brazil.
Letícia VenzCollege of Pharmacy, University of Caxias do Sul, Caxias do Sul, Brazil.
Lessandra MichelinCollege of Pharmacy, University of Caxias do Sul, Caxias do Sul, Brazil.
Bibiana Verlindo AraujoCollege of Pharmacy, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
Leandro TassoHealth Sciences Graduate Program, University of Caxias do Sul, Caxias do Sul, Brazil. ltasso@ucs.br.ORCID http://orcid.org/0000-0001-7102-9204
Universidade de Caxias do Sul · BRUniversidade Federal do Rio Grande do Sul · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThe aim of this study was to investigate the effect of daptomycin against vancomycin-resistant Enterococcus faecium bacteraemia using computer modelling.

methodsData obtained in vitro from time-kill curves were evaluated by PK/PD modelling and Monte Carlo simulations to determine the logarithmic reduction in the number of colony-forming units (CFU)/mL over 18 days of daptomycin treatment at 6, 8, and 10 mg/kg doses every 24 or 48 h and with variations in creatinine clearance (CL

resultsStatic time-kill model was employed to investigate the antibacterial efficacy of constant daptomycin concentrations. The time-kill curve analysis was performed using mathematical modelling based on a Hill coefficient factor. There was an expressive reduction (> 2 Log CFU/mL) over 18 days of daptomycin treatment in 75th percentile of individuals with CL

conclusionsHigher daptomycin doses were associated with higher mortality in time-kill curves. The simulations indicated that independent of the CL

Indexed as

BacteremiaColony Count, MicrobialComputer SimulationDaptomycinEnterococcus faeciumGram-Positive Bacterial InfectionsHumansMicrobial Sensitivity TestsModels, TheoreticalMonte Carlo MethodVancomycin-Resistant EnterococciDaptomycinBacteraemiaDaptomycinEnterococcus faeciumPK/PD modelling

Identifiers

PMID31845296
PMCPMC7058735
OpenAlexW2996318184

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.