Evidence map›Paper›PMID 31845221›Full record

ArticleCurrent medical science2019

Dectin-1 rs3901533 and rs7309123 Polymorphisms Increase Susceptibility to Pulmonary Invasive Fungal Disease in Patients with Acute Myeloid Leukemia from a Chinese Han Population.

Mei-Jing Chen, Rong Hu, Xiao-Ying Jiang, Yong Wu, Zhi-Peng He, Jing-Yi Chen, Li Zhan

Abstract read
PubMed Publisher
In one paragraph

Article in Current medical science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Mei-Jing Chen *The School of Nursing, Fujian Medical University, Fuzhou, 350122, China.
Rong Hu *The School of Nursing, Fujian Medical University, Fuzhou, 350122, China.
Xiao-Ying JiangThe School of Nursing, Fujian Medical University, Fuzhou, 350122, China. jiangxy320@126.com.
Yong WuInstitute of Hematology, Department of Hematology, Union Hospital, Fujian Medical University, Fuzhou, 350001, China. wuyong9195@126.com.
Zhi-Peng HeInstitute of Hematology, Department of Hematology, Union Hospital, Fujian Medical University, Fuzhou, 350001, China.
Jing-Yi ChenThe School of Nursing, Fujian Medical University, Fuzhou, 350122, China.
Li ZhanThe School of Nursing, Fujian Medical University, Fuzhou, 350122, China.
Fujian Medical University · CNUnion Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aimed to assess whether genetic variants of dendritic cell-associated C-type lectine-1 (Dectin-1), Toll-like receptor 2 (TLR2), Toll-like receptor 4 (TLR4), and myeloid differentiation primary response 88 (MyD88) influence the susceptibility to pulmonary invasive fungal disease (IFD) in patients with acute myeloid leukemia (AML) from a Chinese Han population. Eight single nucleotide polymorphisms (SNPs) of Dectin-1 (rs16910526, rs3901533, and rs7309123), TLR2 (rs5743708), TLR4 (rs4986790 and rs4986791) and MyD88 (rs4988453 and rs4988457) in the genomic DNA of 172 adult AML patients were genotyped. Pulmonary IFD was diagnosed as proven or probable according to the 2008 European Organization for Research and Treatment of Cancer/Invasive Fungal Infections Cooperative Group and the National Institute of Allergy and Infectious Diseases Mycoses Study Group (EORTC/MSG) consensus guidelines. SNPs that were significant in the univariate analysis were further analyzed using the multiple logistic regression analysis to determine their association with the occurrence of pulmonary IFD. The mRNA expression of Dectin-1 was detected according to the genotype by quantitative realtime PCR (qRT-PCR), and the correlation of this expression with the occurrence of pulmonary IFD in AML patients was analyzed. Two Dectin-1 intron SNPs (rs3901533 and rs7309123) were found to be significantly associated with the susceptibility to pulmonary IFD in AML patients in a Chinese Han population. Significant associations were noted between pulmonary IFD and Dectin-1 rs3901533 dominant model (G/T+G/G vs. T/T, OR: 2.158; 95% CI: 1.109-4.2, P=0.02), Dectin-1 rs3901533 G allele (OR: 2.201; 95% CI: 1.206-4.019, P=0.01), or Dectin-1 rs7309123 C allele (OR: 1.919; 95% CI: 1.047-3.518, P=0.03). There were no significant associations between pulmonary IFD and the remaining Dectin-1 SNPs (rs16910526), TLR2 (rs5743708), TLR4 (rs4986790 and rs4986791) or MyD88 (rs4988453 and rs4988457). In conclusion, two Dectin-1 SNPs (rs3901533 and rs7309123) are associated with increased susceptibility to pulmonary IFD in AML patients in a Chinese Han population.

Indexed as

Asian PeopleChinaDectin-1FemaleGene Expression RegulationGenetic Predisposition to DiseaseHumansInvasive Fungal InfectionsLectins, C-TypeLeukemia, Myeloid, AcuteLung Diseases, FungalMaleMyeloid Differentiation Factor 88Polymorphism, Single NucleotideToll-Like Receptor 2Toll-Like Receptor 4CLEC7A protein, humanDectin-1Lectins, C-TypeMYD88 protein, humanMyeloid Differentiation Factor 88TLR2 protein, humanTLR4 protein, humanToll-Like Receptor 2Toll-Like Receptor 4acute myeloid leukemiaDectin-1invasive fungal infectionpolymorphisms

Identifiers

PMID31845221
OpenAlexW2995854430

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.