SynthesisQuality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation2020
Niche-related outcomes after caesarean section and quality of life: a focus group study and review of literature.
Synthesis in Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05777837 (Laparoscopic Excision Versus Combined Hysteroscopic and Laparoscopic Repair Without Excision of Large Cesarean Scar Niche), which is not on this map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Laparoscopic Excision Versus Combined Hysteroscopic and Laparoscopic Repair Without Excision of Large Cesarean Scar Niche: A Randomized Controlled Trial
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- Pooled it
- Trial
- Prevalence of cesarean scar disorder in patients 3 years after a first cesarean section.Acta obstetricia et gynecologica Scandinavica · 2025Trial
- Effect of single- versus double-layer uterine closure during caesarean section on postmenstrual spotting (2Close): multicentre, double-blind, randomised controlled superiority trial.BJOG : an international journal of obstetrics and gynaecology · 2021Trial
- Prostaglandin E2-mediated aging microenvironment fuels pathogenic fibrosis in cesarean section scar defect.EMBO molecular medicine · 2026Article
- Effect of cervical changes on the cesarean scar topography after primary cesarean sections: an observational study.BMC pregnancy and childbirth · 2025Observational
- Article
- Robotic-assisted laparoscopic niche repair (RALNR): technique development and pregnancy-associated outcomes.Journal of robotic surgery · 2025Article
- Diagnostic yield of transvaginal ultrasonography versus saline: infused sonohysterography in the evaluation of post-cesarean section uterine niche.Journal of ultrasound · 2025Article
- Pregnancy outcomes in women with cesarean section scar defects and secondary infertility after vaginal repair: a multicenter observational cohort analysis.Frontiers in medicine · 2025Article
- Isthmoceles - Accuracy of imaging diagnosis and clinical correlation with histology: A prospective cohort study.Facts, views & vision in ObGyn · 2024Article
- Clinical analysis of uterine parameters evaluated by preoperative magnetic resonance imaging in patients treated by hysteroscopic approach with previous cesarean scar defect-related abnormal uterine bleeding: a retrospective cohort study.Quantitative imaging in medicine and surgery · 2024Article
- A transvaginal ultrasound-based diagnostic calculator for uterus post-cesarean scar defect.BMC women's health · 2023Article
- Article
- Definition and Criteria for Diagnosing Cesarean Scar Disorder.JAMA network open · 2023Article
- Mode of delivery and maternal sexual wellbeing: A longitudinal study.BJOG : an international journal of obstetrics and gynaecology · 2022Article
- Bacterial colonization at caesarean section defects in women of secondary infertility: an observational study.BMC pregnancy and childbirth · 2022Observational
- Laparoscopic Isthmocele Repair: Efficacy and Benefits before and after Subsequent Cesarean Section.Journal of clinical medicine · 2021Article
- Symptoms and Quality of Life Changes after Hysteroscopic Treatment in Patients with Symptomatic Isthmocele-Preliminary Results.Journal of clinical medicine · 2021Article
- Comparative Study of USG and MRI in Evaluation of Isthmocele.Journal of obstetrics and gynaecology of India · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundA niche in the uterus, present in 60% of women after caesarean section (CS), is associated with several gynaecological symptoms and possibly with subfertility. Studies that focus on quality of life (QoL) in relation to a niche are lacking. PURPOSE: To identify niche-related outcomes that influence QoL and to compare patient-reported outcomes with outcomes studied in the literature.
methodsTwo focus group discussions (FGDs, N = 8 and 5) were conducted in Amsterdam UMC-location VUmc. Participants were Dutch patients with a large niche, with (planned) surgical treatment for their symptoms. Niche-related symptoms and impact on functioning or participation were fixed topics. The transcripts of the FGDs were coded into outcomes, themes and domains of QoL according to the WHOQOL model. Additionally, participants created a top five important outcomes. Next, we performed a systematic review (SR) on niche-related outcomes and compared the FGDs with niche-related outcomes from the SR.
resultsIn four domains (physical health, psychological domain, social relationships and environment), fifteen themes were reported in the FGDs. Abnormal uterine bleeding (AUB), subfertility, sexual activity, abdominal pain and self-esteem were themes prioritised by participants. In the literature, gynaecological symptoms and reproductive outcomes were predominantly studied. Sexuality and self-esteem were prioritised in the FGDs but hardly or never studied in the literature.
conclusionWe found a broad range of niche-related outcomes influencing QoL. Apart from symptoms evaluated in the literature such as AUB, abdominal pain and subfertility, clinicians and researchers should be more aware of sexual activity and self-esteem in this population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.