Evidence map›Paper›PMID 31844926›Full record

ArticleArchives of toxicology2020

Deregulation of autophagy is involved in nephrotoxicity of arsenite and fluoride exposure during gestation to puberty in rat offspring.

Xiaolin Tian, Jiaxin Xie, Xushen Chen, Nisha Dong, Jing Feng, Yi Gao, Fengjie Tian, Wenping Zhang, Yulan Qiu, Ruiyan Niu and 2 more

Open access · greenAbstract read
In one paragraph

Article in Archives of toxicology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 30 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Xiaolin TianSchool of Public Health, Shanxi Medical University, Taiyuan, 030001, Shanxi, China.
Jiaxin XieSchool of Public Health, Shanxi Medical University, Taiyuan, 030001, Shanxi, China.
Xushen ChenDepartment of Epidemiology and Environmental Health, School of Public Health and Health Professions, The State University of New York, Buffalo, NY, 14214, USA.
Nisha DongSchool of Public Health, Shanxi Medical University, Taiyuan, 030001, Shanxi, China.
Jing FengShanxi Key Laboratory of Experimental Animal and Human Disease Animal Models, Shanxi Medical University, Taiyuan, 030001, Shanxi, China.
Yi GaoSchool of Public Health, Shanxi Medical University, Taiyuan, 030001, Shanxi, China.
Fengjie TianSchool of Public Health, Shanxi Medical University, Taiyuan, 030001, Shanxi, China.
Wenping ZhangSchool of Public Health, Shanxi Medical University, Taiyuan, 030001, Shanxi, China.
Yulan QiuSchool of Public Health, Shanxi Medical University, Taiyuan, 030001, Shanxi, China.
Ruiyan NiuShanxi Key Laboratory of Ecological Animal Science and Environmental Veterinary Medicine, Shanxi Agricultural University, Taigu, 030801, Shanxi, China.
Xuefeng RenDepartment of Epidemiology and Environmental Health, School of Public Health and Health Professions, The State University of New York, Buffalo, NY, 14214, USA.
Xiaoyan YanSchool of Public Health, Shanxi Medical University, Taiyuan, 030001, Shanxi, China. yanxiaoyan@sxmu.edu.cn.ORCID 0000-0003-0809-3670
Shanxi Medical University · CNShanxi Agricultural University · CNJacobs Institute · USUniversity at Buffalo, State University of New York · US

Funding

Mechanisms and Outcomes of MMAsIII induced Alterations in Histone AcetylationR01ES022629 · NIEHS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI REN, XUEFENG · 2014 to 2017
$1.4M
NIEHS NIH HHS R01 ES022629
6 · The paper itself

Abstract

Exposure to fluoride (F) or arsenite (As) through contaminated drinking water has been associated with chronic nephrotoxicity in humans. Autophagy is a regulated mechanism ubiquitous for the body in a toxic environment with F and As, but the underlying mechanisms of autophagy in the single or combined nephrotoxicity of F and As are unclear. In the present study, we established a rat model of prenatal and postnatal exposure to F and As with the aim of investigating the mechanism underlying nephrotoxicity of these pollutants in offspring. Rats were randomly divided into four groups that received NaF (100 mg/L), NaAsO

Indexed as

AnimalsArsenitesAutophagyEnvironmental PollutantsFemaleFluoridesKidneyMalePregnancyRatsRenal InsufficiencySexual MaturationarseniteArsenitesEnvironmental PollutantsFluoridesArseniteAutophagyFluorideNephrotoxicity

Identifiers

PMID31844926
PMCPMC7085982
OpenAlexW2996294381

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.