ArticleEnvironmental epidemiology (Philadelphia, Pa.)2019
Prenatal exposure to metal mixture and sex-specific birth outcomes in the New Hampshire Birth Cohort Study.
Article in Environmental epidemiology (Philadelphia, Pa.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 2 of them syntheses that pooled it.
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Who cites it
44 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Prenatal air pollution exposure in relation to the telomere-mitochondrial axis of aging at birth: A systematic review.Environmental research · 2024Pooled it
- Toenails as a biomarker of exposure to arsenic: A review.Environmental research · 2021Pooled it
- Mind the Litter: The Critical Role of Intralitter Variables in Reproductive and Developmental Toxicology Research.Birth defects research · 2026Review
- Maternal and Newborn Factors Associated with Meconium Metal Concentrations: A Cross-Sectional Study.Toxics · 2026Article
- Effects of maternal arsenic exposure on birth outcomes using harmonized data across three birth cohorts.Toxicology and environmental health sciences · 2026Article
- Associations between prenatal metal exposure, gene variants, and birth size in Taiwan Birth Panel Study.Pediatric research · 2026Article
- Prenatal exposure to essential and toxic elements in relation to infant growth trajectories.Environmental health : a global access science source · 2026Article
- Early Life Exposure To Multiple Metals, Nutrition, and Growth in Children - A Scoping Review.Current environmental health reports · 2025Article
- Association between urinary heavy metal concentrations, thyroid hormones, and birth outcomes among pregnant women in Isfahan City.Scientific reports · 2025Article
- Using transcriptomic signatures to elucidate individual and mixture effects of inorganic arsenic and manganese in human placental trophoblast HTR-8/SVneo cells.Toxicological sciences : an official journal of the Society of Toxicology · 2025Article
- Using a neural network to derive early childhood neurodevelopmental profiles in the New Hampshire Birth Cohort Study.BMJ public health · 2025Article
- Measuring Greenspace in Rural Areas for Studies of Birth Outcomes: A Comparison of Street View Data and Satellite Data.GeoHealth · 2024Article
- The Siren Song of Cicadas: Early-Life Pesticide Exposure and Later-Life Male Mortality.Journal of environmental economics and management · 2024Article
- Greenspace and Land Cover Diversity During Pregnancy in a Rural Region, and Associations With Birth Outcomes.GeoHealth · 2024Article
- Periconceptional and Prenatal Exposure to Metals and Extracellular Vesicle and Particle miRNAs in Human Milk: A Pilot Study.Exposure and health · 2023Article
- Prenatal Metal Exposure Alters the Placental Proteome in a Sex-Dependent Manner in Extremely Low Gestational Age Newborns: Links to Gestational Age.International journal of molecular sciences · 2023Article
- Associations between exposure to cadmium, lead, mercury and mixtures and women's infertility and long-term amenorrhea.Archives of public health = Archives belges de sante publique · 2023Article
- Metals and per- and polyfluoroalkyl substances mixtures and birth outcomes in the New Hampshire Birth Cohort Study: Beyond single-class mixture approaches.Chemosphere · 2023Article
- Maternal Exposure to Potentially Toxic Metals and Birth Weight: Preliminary Results from the DSAN-12M Birth Cohort in the Recôncavo Baiano, Brazil.International journal of environmental research and public health · 2023Article
- Individual, Independent, and Joint Associations of Toxic Metals and Manganese on Hypertensive Disorders of Pregnancy: Results from the MIREC Canadian Pregnancy Cohort.Environmental health perspectives · 2023Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
backgroundIn utero exposure to individual metals may impact fetal growth, though little is known about the effects of exposure to metal mixtures. Therefore, we investigated joint effects of in utero exposure to a mixture of As (arsenic), Mn (manganese), and Pb (lead) on newborn outcomes in a United States population.
methodsConcentrations of As, Mn, and Pb were determined in maternal postpartum toenail samples, a biomarker of in utero exposure, from 989 maternal-infant pairs (492 females and 497 males). Newborns' anthropometric characteristics, including head circumference, length, and weight, were obtained from medical records. The joint effects of the three metals were modeled using Bayesian kernel machine regression and linear regression. Both sex-combined and sex-stratified statistical analyses were performed.
resultsWe observed an inverted-U-shape association between maternal toenail Mn concentrations and newborn head circumference, particularly among female infants. Concentrations of Pb were related to reduced head circumference, weight, and length, especially among females at lower concentrations of the other metals. Overall, toenail As concentrations were related to reduced head circumference, especially among males, and an increase in birth length and weight among females. We found little evidence of As interactions with other metals within the mixture.
conclusionsOur findings suggest that in utero metal mixture exposures may influence birth outcomes, and that such relations may differ by infant sex.
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